Aug 2026· Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan· Vol 46 4, pp.
916-926
· 0 citations
Medicine
TL;DR
The study systematically explored JHD's mechanism by cross-integrating metabolomics-derived biomarker pathways with network pharmacology predictions, and it may be a useful alternative therapy for the treatment of TD.
CNZP exhibits significant therapeutic effects on RA, potentially by downregulating NOS1 expression and subsequently correcting the metabolic imbalance of L-arginine, and this preclinical study provides mechanistic evidence for the anti-RA effect of CNZP.
Zhi-Qiang Li, Liang Cao, Jia-Jia Wang et al.· Clinical Rheumatology· 0 citations
This integrative approach confirms that WZDP confers therapeutic benefits in MASLD through coordinated regulation of neuroactive ligand–receptor interaction, bile acid biosynthesis, phospholipase D signaling, and arginine–proline metabolism.
Chaibei Zhixian Decoction may regulate ferroptosis-related pathways in epilepsy and provide mechanistic insights; however, ferroptosis-specific markers were not measured directly, the metabolomic screen was not adjusted for multiple comparisons, and the predicted compound-target relationships require further experiment...
Xiao-Hui Wang, Li-Yuan Nie, Miao Yu et al.· Journal of chromatography. B...· 0 citations
Huoxue Huayu Gel Plaster (HXHYGP) is a topical traditional Chinese medicine preparation used for oxaliplatin-induced peripheral neuropathy (OIPN), but its locally exposed bioactive components remain unclear. This study developed an integrated strategy combining pharmacodynamic evaluation, UHPLC-HRMS-based tissue pharma...
Yu-Jiao Hua, Yan Zhang, Yong-Juan Ding et al.· Biomedical chromotography· 0 citations
BXXD alleviates T2DM-associated metabolic dysregulation by activating the AMPK/SIRT1-mitophagy axis and suppressing inflammation, providing mechanistic evidence supporting further translational investigation of BXXD for T2DM.
Li-Juan Du, Yupeng Chen, Xiu-Gang Zhang et al.· 3 Biotech· 0 citations
These findings provide mechanistic evidence supporting the traditional medicinal use of P. pyrifolia and establish a theoretical framework to develop phytopharmaceuticals for inflammatory diseases.
Ducdat Le, D. Rhyu, Mi-Na Lee· Antioxidants· 0 citations
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