Aug 2026· Cardiovascular Drugs and Therapy· 0 citations· 37 references
Medicine
TL;DR
Why injectable lipid-lowering therapies in advanced CKD merits serious consideration is highlighted - not only for their potent and durable lipid-lowering effects, but also for their ability to target other paths that contribute to the excess CV risk not captured by LDL alone.
A stage-specific framework for integrating injectable therapies into CKD pathways is proposed—covering patient selection, sequencing, monitoring and implementation—and outline priorities for CKD-enriched outcome trials, kidney-relevant endpoints, and the integration of emerging lipoprotein(a)-targeted injectables into...
J. Baharani, Sudarshan Ramachandran· Lipidology· 0 citations
A comprehensive overview of emerging pharmacologic and interventional approaches for BP management in nondialysis CKD is provided, highlighting mechanism-driven innovations and their potential clinical translation.
A. Damianaki, P. Iliakis, A. Vakka et al.· Journal of Hypertension· 0 citations
Diabetes mellitus (DM) and chronic kidney disease (CKD) frequently coexist and together create a 'triple threat' with dyslipidaemia, enhancing the risk for cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) leads to altered lipid metabolism through insulin resistance, inflammation and oxidative stres...
A. Forrest, P. Majety, Stéphanie B. Mayer et al.· Diabetes, obesity and metabo...· 0 citations
The role of low-density lipoprotein cholesterol (LDL-C) in the excess cardiovascular risk associated with CKD is addressed and the impact of both traditional and novel LDL-C-lowering therapies across the entire spectrum of CKD is examined.
R. Minutolo, M. Ravera, M. Cozzolino et al.· Giornale Italiano di Nefrolo...· 0 citations
Chronic kidney disease (CKD) and cardiovascular disease (CVD) are major causes of morbidity and mortality in people with type 2 diabetes (T2D). Contemporary CKD guidelines increasingly support incorporation of glucagon-like peptide-1 receptor agonists (GLP-1RAs) as an additional pillar of cardiorenal therapy alongside...
E. Pedagogos, Roger Chen, Adam J. Nelson et al.· Internal medicine journal (P...· 0 citations
Mechanical insights from translational studies further suggest that GLP-1 receptor activation promotes metabolic decongestion, improves intrarenal hemodynamics, and attenuates inflammatory and fibrotic pathways, with emerging signals for cardiovascular and renal benefit.
Yaeni Kim, Eun Young Lee· Kidney Research and Clinical...· 0 citations
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