TL;DR
The regulatory functions of bacterial sRNAs are summarized, the molecular mechanisms that govern their expression and regulatory consequences are described, and the many exciting open questions surrounding sRNA-mediated gene regulation in bacteria are discussed.
Abstract Bacterial regulatory small RNAs (sRNAs) are integral components of posttranscriptional control, shaping environmental adaptation, metabolic homeostasis, and virulence. Advances in transcriptomics and RNA technologies have greatly expanded the repertoire of bacterial sRNAs and revealed their extensive roles in...
This review discusses six primary transcription-dependent regulatory mechanisms: transcription-dependent activation, chromatin remodeling, R-loop formation, transcriptional condensate formation, DNA looping, and transcriptional interference.
A network‐based framework for exploiting RBPs as therapeutic vulnerabilities and for advancing next‐generation precision oncology is provided, integrating mechanistic principles with translational evidence.
This work highlights non-canonical transcriptional kinases that could operate alongside and beyond CDKs to modulate transcription by RNAPII, and discusses how these kinases could introduce context-specific CTD modifications that enable transcriptional plasticity, facilitate rapid loci-specific activation, and integrate...
This chapter provides an overview of numerous computational approaches developed to reconstruct circRNA-miRNA-mRNA networks, ranging from specific circRNA-oriented applications to sequencing-based tools, each with distinct strengths and limitations.
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