GPER1/GIPC1-AMPKα signaling alleviates hepatic steatosis via regulating lipid metabolism and fatty acid oxidation-related gene expression: A novel target in MASLD.

Open access Sep 2026

Hepatic Usp2 orchestrates de novo lipogenesis through G3bp2 stabilization and β-catenin activation

The escalating global burden of metabolic diseases including obesity, type 2 diabetes, and metabolic dysfunction-associated fatty liver disease (MAFLD)-highlights an urgent need to identify new therapeutic targets. Although elevated hepatic de novo lipogenesis (DNL) is a hallmark of metabolic dysfunction, targeting i...

Wei Wang, Hui Wang, Yi-Han Liu et al. · Cell Death Discovery · 0 citations

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Open access Sep 2026

Arhgap25 Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Driving Kupffer Cell Polarization via Activation of the AKT/mTOR Signaling Pathway.

BACKGROUND Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading global health burden, yet the regulatory nodes linking hepatic immune dysregulation to metabolic perturbations remain incompletely understood. METHODS We integrated bulk and single-cell RNA sequencing (scRNA-seq) to identify core...

Yan Wang, Shuang-Shuang Lu · Frontiers in Bioscience · 0 citations

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Sep 2026

Targeting lipid metabolism-associated lncHMGCS1 suppressed cell proliferation and restored intracellular lipid homeostasis by regulating ACSL3 in gastric cancer.

Previous work has indicated that lipid metabolic reprogramming plays a critical role in gastric cancer (GC) development, yet the underlying molecular mechanisms remain largely undefined. In the present study, we identified a novel lipid metabolism-associated long non-coding RNA, 3-Hydroxy-3-Methylglutaryl-CoA Synthase...

Qiang Yang, Yu-Yang He, Le-Jia Wang et al. · European Journal of Pharmaco... · 0 citations

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Open access Aug 2026

Effects of Bound Polyphenols on Lipid Metabolism in HepG2 Cells and Glucose-Induced C. elegans Models

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disease associated with insulin resistance and hepatic lipid accumulation. Polyphenols have attracted considerable attention for their hepatoprotective and lipid-lowering activities. Our previous studies characterized a bound p...

Israr Ghani, Qin-Qin Qiao, Song-Tao Li et al. · International Journal of Mol... · 0 citations

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Open access Sep 2026

Yinqi Tiaozhi Decoction ameliorates hepatic steatosis in metabolic dysfunction-associated fatty liver disease by regulating the miR-122-5p/FOXO3 axis to modulate lipid metabolism and oxidative stress

Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD) lacks targeted pharmacotherapies. Objective: This study investigates whether Yinqi Tiaozhi Decoction (YQTZD) alleviates MAFLD via the miR-122-5p/forkhead box O3 (FOXO3) axis. Methods: MAFLD was modeled using oleic acid–treated AML12 cells and ra...

Li-Ping Zhou, Yan-Feng Huang, Feng Tian et al. · Eurasian Journal of Medicine... · 0 citations

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Open access Aug 2026

Deletion of protein tyrosine phosphatase 1B in hepatocytes attenuates inflammation, steatosis, and fibrosis in a dietary mouse model of metabolic dysfunction-associated steatohepatitis

Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of liver-related morbidity and mortality. The current interventions are limited, underscoring the need for novel mechanism-based therapies. Protein tyrosine phosphatase 1B (PTP1B) regulates phosphotyrosine signaling and hepatic metabolism,...

Ming-Fo Hsu, Yoshihiro Ito, Ulrik N. Mjaaseth et al. · Molecular Medicine · 0 citations

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