Regulatory role of lncRNA DANCR in osteogenic differentiation of bone marrow mesenchymal stem cells through targeting the miR-19a-3p/PTEN/AKT/mTOR pathway.
Investigation of lncRNA DANCR's role in osteogenic differentiation of bone marrow mesenchymal stem cells and underlying mechanisms found it potentiated the OD capability of BMSCs, as evidenced by increased ALP activity, calcium nodule formation, and elevated expression of OPN, RUNX2, and OCN.
Steroid-induced osteonecrosis of the femoral head (SONFH) is characterized by disrupted osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). The long noncoding RNA HOTAIR is aberrantly upregulated in SONFH-BMSCs, yet its functional role in the differentiation imbalance remains in...
Min Yi, Fei-Fei Lin, Zhen-Wu Du et al.· Frontiers in Genetics· 0 citations
Inhibition of the PTBP1-PRKCZ axis activates autophagy to reprogram the osteogenic-adipogenic differentiation balance of BMSCs, thereby mitigating osteoporosis.
Estrogen regulates METTL3-mediated m6A modification to stabilize SATB2 mRNA via IGF2BP1, resulting in alleviated BMSC senescence and promoted OD, which provides a theoretical basis and potential intervention targets for BMSC-based anti-osteoporosis treatment strategies.
Feng-Cheng Zhu, Yong-Gang Zhao, Xu-Guo Fan et al.· Pathology, Research and Prac...· 0 citations
Background Myeloma bone disease (MBD) is driven by excessive osteoclast activation and progressive bone destruction, but the role of exosomal circular RNAs (circRNAs) from myeloma cells remains unclear. Methods Exosomes from U266 and MM1S cells were isolated and used to treat THP-1 cells. Osteoclast differentiation was...
N. Yi, Muyun Wu, Xiao-Jie Ma et al.· Frontiers in Oncology· 0 citations
Background Building on our previous work, we found that human omental adipose‐derived mesenchymal stem cells (ADSCs) promote ovarian cancer growth and metastasis by inducing PAX8, a key oncogenic transcription factor in ovarian cancer. TAZ is a core downstream effector of the Hippo signaling pathway, closely associated...
Ning-Xia Sun, Jing Wang, Hanxu Yang et al.· Stem Cells International· 0 citations
The quality of cashmere fiber is fundamentally determined by the embryonic morphogenesis of hair follicles, a process highly dependent on the normal function of hair follicle stem cells (HFSCs). MicroRNAs (miRNAs) are key post-transcriptional regulators, but their specific roles in cashmere goat hair follicle developme...
Yi Guo, Niu Wang, Xiao-Jie Hou et al.· Animal Genetics· 0 citations
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