AGENT-O: A Semantic Agent Card Framework for Interoperable and Governed Healthcare AI Agents

Abstract

AGENT-O is a modular ontology framework that defines a semantic Agent Card for representing health-oriented AI agent systems and supports assessment of reporting completeness in scientific publications. AGENT-O was developed as an OWL 2/RDF ontology covering runtime, models, workflow, tools, clinical use, evaluation, provenance, governance, and reporting assessment. Evaluation included ontology inventory, OWL-RL reasoning, three SHACL suites, 12 SPARQL competency queries, three cases, and model-assisted reporting-completeness assessment of 279 papers across five dimensions. The ontology contained 1,962 RDF triples and 1,922 Protege axioms, with 252 active classes, 198 active object properties, and 51 datatype properties. All SHACL suites conformed on example graphs, all competency queries returned prespecified evidence, and all 279 papers were scored. Incomplete reporting was highest for runtime/architecture (84.6%), governance/safety (82.8%), and provenance/reproducibility (78.1%), compared with evaluation (25.8%) and benchmark-process alignment (29.8%). AGENT-O supported semantic Agent Card representation and reporting assessment while revealing an evaluation-specification gap: evaluation and benchmark procedures were reported more consistently than runtime architecture, governance, and reproducibility. AGENT-O provides a reusable ontology, semantic Agent Card profile, and reporting-completeness workflow for structured reporting and gap identification, but does not assess agent quality or deployment readiness.