Study on the Characterization of Transition Metal Complexes and Their Antibacterial Properties

Abstract

This study reviews on the Macrocyclic ligands that are polydentate ligands that contain donor atoms either incorporated or linked to the cyclic backbone and have been shown to have biological importance in a variety of investigations. Using the template technique, tetraaza macrocyclic complexes of transition metals Ni(II), Cu(II), Fe(III), and Mn(II) were produced in methanolic conditions. These complexes lacked hygroscopicity and were composed entirely of crystalline solids. The structures of these complexes were determined using the analytical methods UV-Vis and IR Spectroscopy. Antibacterial activity of macrocyclic complexes (1-6) was evaluated against Gram-negative (Escherichia coli and Vibrio cholerae) and Gram-positive microorganisms (Bacillus subtilis and Staphylococcus aureus). We observed in this work that these manufactured complexes had only a weak antibacterial activity, with the exception of macrocyclic complex (6), which exhibited moderate antibacterial activity.