Skip to content

Nanomedicine for biofilm associated infections: opportunities, challenges, and clinical translation

Aug 2026 · Microfluidics and Nanofluidics · Vol 30 · 0 citations · 111 references

TL;DR

Comparative studies suggest that combination approaches, including enzyme functionalized or stimuli responsive nanoparticles paired with antibiotics, may outperform single modality treatments by simultaneously disrupting the biofilm matrix and delivering active agents.

View source

Similar papers

Review Open access 2026

Nanoparticle-antibiotic synergy against bacterial biofilms: mechanisms, therapeutic potential, and future directions

Bacterial biofilms pose significant challenges in clinical and industrial settings because of their resistance up to 1000-fold higher than that of planktonic bacteria. This resistance arises from extracellular polymeric matrix, reduced metabolic activity, and horizontal gene transfer. The growing burden of biofilm-asso...

I. C. Oladipo, K. Oloyede, O. B. Ogunleke et al. · 0 citations
Review Open access Sep 2026

Nanodrug Delivery Systems for Lower Respiratory Infections: Pulmonary Targeting, Anti-Infective Applications, and Translational Challenges

This review systematically summarize recent advances in NDDS for LRIs, with emphasis on the design principles and functional characteristics of lipid-based, polymeric, inorganic, and hybrid nanocarriers, and connects these platforms with disease-specific therapeutic challenges in bacterial pneumonia, tuberculosis, vira...

Wen-bin Zhu, Ting-Ji Liu, Guang-Liang Cheng et al. · 0 citations
Review Open access Aug 2026

Lipid nanoparticle-based drug delivery for invasive fungal infections: engineering strategies, therapeutic advances, clinical translation, and future perspectives

This review critically evaluates advances in LNP formulation engineering, pathogen-specific therapeutic applications, biological mechanisms, manufacturing scalability, Quality-by-Design (QbD), regulatory expectations, patent landscape, and the principal barriers limiting successful clinical translation of next-generati...

Abdul Shadab · 0 citations
Review Open access Sep 2026

Nanomedicine against antimicrobial resistance: mechanistic insights and next-generation therapeutic potential

This review comprehensively examines resistance mechanisms across major microbial pathogens and discusses the evolution of nanomedicine as an advanced platform for combating AMR, highlighting the synergistic interactions between nanomaterials and conventional antimicrobial agents that enhance therapeutic efficacy and r...

Vishal L. Handa, Benedict B. Vyas, Abhishek Padhi et al. · 0 citations
Conference Open access Sep 2026

A Comprehensive Review of Antimicrobial Nanoformulations: Engineered to Combat Biofilm-Associated Infections

This review establishes a consolidated evidence base for the design of next-generation antimicrobial nanoformulations, highlights their potential to address biofilm-associated infections, and identifies key knowledge gaps and translation barriers that must be addressed to realize their therapeutic promise.

Praveen Kumar Annagowni, Renuka Gudepu, S. Dahariya et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.