Synergistic effects of luteolin and Lactobacillus rhamnosus on methicillin-resistant Staphylococcus aureus biofilm inhibition: in vitro and in silico molecular deployment studies.
Results demonstrate that luteolin combined with L. rhamnosus bacterial suspension natant represents a promising natural therapeutic strategy for controlling MRSA infections by simultaneously targeting bacterial growth, biofilm formation, and virulence while maintaining acceptable biocompatibility.
The synergistic application of baicalin and sodium oxacillin effectively impedes MRSA biofilm development and virulence factor synthesis, thereby attenuating pathogenicity in a mouse model of peritonitis induced by MRSA USA300 strain.
ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) presents a significant threat to public health owing to its high pathogenicity and multidrug resistance. The use of antibiotic combinations, including antibiotics and antibiotic adjuvants, has proven effective in treating drug-resistant bacterial infections. T...
Rui-Huan Chen, Ling-Yuan Guo, Yi-Mai Deng et al.· Microbiology spectrum· 0 citations
Overall, L. rhamnosus ATCC 7469 CFS exhibited substantial antimicrobial and antibiofilm activity against A. baumannii and S. aureus, supporting further investigation of Lactobacillus-derived CFS as a potential local antimicrobial strategy.
Mariana Silveira Mello Silva, P. Halicki, C. J. Scaini et al.· Brazilian Journal of Microbi...· 0 citations
Gliotoxin inhibited planktonic growth and significantly reduced the biomass and viability of biofilms in a concentration-dependent manner, and its combination with conventional antibiotics showed strong synergy, drastically decreasing bacterial survival.
M. Llamosí, J. Sempere, Alicia Gómez-López et al.· Journal of Fungi· 0 citations
The increasing prevalence of antimicrobial resistance (AMR) and biofilm-associated infections poses significant challenges to public health. This study investigated the antibacterial and antibiofilm potential of ethanol extracts of Baccaurea ramiflora Lour. (B. ramiflora) peel (BRP) and seed (BRS) extract, combined wit...
Tripti Paul, Saad Ahmed Sami, Ashik Mosaddik et al.· Clinical Phytoscience· 0 citations
INTRODUCTION
Antimicrobial resistance, particularly when associated with biofilm formation, represents a major global health challenge. In this context, this study aimed to design, synthesize, and evaluate the in vitro biological activity of (E,E)-farnesylethane-1,2-diamine (4a) and (E,E)-farnesylpiperazine (4b), as di...
T. Ribeiro, Grazielle Aparecida dos Santos, Thainá Freitas et al.· Current Topics in Medicinal...· 0 citations
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