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Open access Sep 2026

Circulating PCSK9: A new frontier in cancer risk stratification for obese diabetics.

This study investigated potential plasma biomarkers associated with cancer risk and mortality in patients with type 2 diabetes mellitus (T2DM), a population known to have an increased cancer incidence and poorer outcomes compared with non-diabetic individuals. Traditional metabolic indicators, including blood pressure,...

Lien-Cheng Tsao, Chen-Ling Kuo, Yu-Shan Cheng et al. · 0 citations
Open access Sep 2026

Association of circulating ANGPTL3 level with all-cause and cardiovascular mortality

Angiopoietin-like protein 3 (ANGPTL3) is a liver-derived regulator of triglyceride and cholesterol metabolism and has emerged as a notable therapeutic target for dyslipidemia [1]. However, population-level evidence linking ANGPTL3 level to mortality outcomes remains limited. Using data from UK Biobank [2], we evaluated...

Shao-Yang Yan, Bo-Da Zhou · 0 citations
Sep 2026

Associations of IDL cholesterol and LDL α-tocopherol with diabetic kidney disease in type 2 diabetes.

AIMS Patients with type 2 diabetes mellitus (T2DM) commonly exhibit atherogenic dyslipidemia and increased oxidative stress, which may contribute to the development and progression of diabetic kidney disease (DKD). We investigated the associations of intermediate-density lipoprotein cholesterol (IDL-C) and α-tocopherol...

Y. Hirowatari, Tatsuya Iwasaki, D. Manita et al. · 0 citations
Open access Oct 2026

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway.

INTRODUCTION Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid-lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non-drug treatment using double-filtration plas...

Yun Cheng, Lan Li, Qing-Mei Yang et al. · 0 citations
Open access Jan 2026

Dysregulation of Plasma Nonessential Amino Acids in Early‐Stage Type 2 Diabetes Mellitus

The study revealed that newly diagnosed T2DM and prediabetes are associated with increased levels of certain nonessential amino acids and decreased serine, arginine, cystine, glutamine, and glycine compared to healthy controls.

A. A. H. Al-Rubaye, W. E. Jasim, Ahmed A. Mohsin · 0 citations
Open access Sep 2026

Elevated Markers of Intestinal Barrier Dysfunction and TLR2 Ligands in Individuals with Type 1 Diabetes

Abstract Studies suggest that alterations of intestinal barrier function and a subsequent increased translocation of bacterial endotoxins may be critical in type 1 diabetes mellitus (T1DM) and may contribute to the proinflammatory state of patients. If Gram-positive derived bacterial toxins are also altered in the sett...

N. Noorwali, R. Staltner, Aleksejs Fedulovs et al. · 0 citations

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