Biomedical Protocol Information Extraction Dataset (BioPIE) is introduced, a dataset providing procedure-centric KGs that captures entities, actions, and relations at a scale sufficient for reasoning across biomedical protocols that demonstrate improved understanding performance on both the HID and MSR question sets.
Abstract
Understanding biomedical experiments provides a foundation for downstream tasks, e.g., laboratory automation, and facilitates effective cross-disciplinary communication. Two challenges, High Information Density (HID) and Multi-Step Reasoning (MSR), pose unique difficulties for precise automatic experimental understanding. Extracting structured knowledge, e.g., Knowledge Graphs (KGs), is an effective approach to address the HID and MSR. However, existing biomedical datasets for structured knowledge Information Extraction (IE) are limited to a general or coarse-grained level, hindering fine-grained experimental understanding. To address this gap, we introduce Biomedical Protocol Information Extraction Dataset (BioPIE), a dataset providing procedure-centric KGs that captures entities, actions, and relations at a scale sufficient for reasoning across biomedical protocols. We evaluate both supervised and LLM-based IE methods on BioPIE to verify its effectiveness, and implement a biomedical question answering system to provide a quantitative illustration of BioPIE's effectiveness for downstream understanding tasks. The experimental results demonstrate improved understanding performance on both the HID and MSR question sets.
This work presents a scalable, reproducible framework for evaluating, optimizing, and interpreting LLMs for biomedical knowledge extraction, with a focus on gene–gene regulatory relation prediction, pathway component recognition, multimodal pathway figure understanding, and automated prompt optimization.
Results demonstrate that InfoFlowEX equips LLMs with robust adaptability, achieving consistent gains over baselines with minimal task-specific customization, highlighting InfoFlowEX for real-world biomedical applications.
Wuyang Lan, Siqi Zhang, Wenzheng Wang et al.· Cell Reports Medicine· 0 citations
By unifying fragmented research and enabling robust data exploration, UKB-KG emerges as a powerful tool for advancing biomedical research and driving innovative healthcare applications.
Z. Wang, J. Wang, Y. Shen et al.· medRxiv· 0 citations
Initial experiments on heart-failure-focused clinical question answering show that CGX improves evidence retrieval quality and perceived answer reliability over conventional retrieval methods, while reducing total graph construction time by 69.7% under the same input corpus and hardware setting.
Dat T. Nguyen, Ngoc-Anh Thi Le, Binh T. D. Trinh et al.· Journal of Biomedical Inform...· 0 citations
Background Accessing large-scale clinical and biomedical databases remains a significant barrier for clinicians and researchers, requiring substantial computational expertise. Agentic artificial intelligence frameworks, in which large language models (LLMs) orchestrate multi-step reasoning and query execution under int...
Gianmarco Bellucci, W. Gu, Peter W. Rose et al.· Frontiers in Artificial Inte...· 0 citations
Identifying causal connections between existing drugs and mechanistic profiles of diseases is a foundational step for effective drug repurposing. Although knowledge graphs (KGs) are highly suited for consolidating biomedical databases and tracking these connections, a single biomedical KG is constrained by its ingestio...
Piotr Kaniewski, E. K. Carter, Daniel J. Rhodes et al.· bioRxiv· 0 citations
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