Jun 2022· Neural Information Processing Systems· Vol abs/2206.09012· 316 citations· ⚡ 15 influential· 56 references
Computer Science
TL;DR
The possibility of inferring high-dimensional data inference in a model that consists of a prior and an auxiliary differentiable constraint given some additional information is considered, thereby allowing a range of potential applications in adapting models to new domains and tasks.
Abstract
We consider the problem of inferring high-dimensional data $\mathbf{x}$ in a model that consists of a prior $p(\mathbf{x})$ and an auxiliary differentiable constraint $c(\mathbf{x},\mathbf{y})$ on $x$ given some additional information $\mathbf{y}$. In this paper, the prior is an independently trained denoising diffusion generative model. The auxiliary constraint is expected to have a differentiable form, but can come from diverse sources. The possibility of such inference turns diffusion models into plug-and-play modules, thereby allowing a range of potential applications in adapting models to new domains and tasks, such as conditional generation or image segmentation. The structure of diffusion models allows us to perform approximate inference by iterating differentiation through the fixed denoising network enriched with different amounts of noise at each step. Considering many noised versions of $\mathbf{x}$ in evaluation of its fitness is a novel search mechanism that may lead to new algorithms for solving combinatorial optimization problems.
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The main innovation is to develop stochastic control theory within the branching OGP framework, significantly expanding the settings in which it locates an exact algorithmic threshold.
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This work proposes a statistically consistent and scalable estimator for score differences based on Sobolev regularization and demonstrates its effectiveness on real-world tasks, including transfer learning for ECG signal generation, where it substantially outperforms non-regularized score difference estimators in down...
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Microsoft Research Blog· microsoft.comAug 11, 2026
Radiology AI is evolving beyond report generation. CARE-X explores a unified approach that combines flexible reasoning, calibrated predictions, and measurement-based tools for chest X-ray interpretation. The post Introducing CARE-X: Towards Clinically Useful Radiology VLMs with Auxiliary Supervision, Reward-Aligned Learning, and Tool-Augmented Measurement appeared first on Microsoft Research.