Clinical studies, including own investigations, demonstrated a negative correlation between the ratio of 2-hydroxyestrone to 16 α -hydroxyestrone and breast cancer risk, but the design and interpretation of such studies should consider factors influencing metabolic pattern such as diet, physical activity, smoking as well as internal diseases and certain drugs.
A clinical proof-of-concept-study in a randomized, open-label, parallel group design, with promising results must be confirmed in a suitable larger clinical study on progesterone-only-oral contraceptive results.
M. Oettel, P. S. Kochhar, H. Osterwald et al.· 0 citations
The multi-target pharmacology of GP is conceptually consistent with the complex, systemic nature of endocrine therapy-related adverse effects, suggesting that a single botanical agent could simultaneously address metabolic, neurological, immune, and organ-related sequelae.
K. Luo, C. Yao, Ling Gao et al.· The Natural Products Journal· 0 citations
Worldwide, increasing comorbidity among women has led to a rapid rise in the prevalence of hyperproliferative estrogendependent diseases of the reproductive system (endometriosis, adenomyosis, uterine fibroids, endometrial hyperplasia, and benign breast dysplasia). In addition, the detection of combined forms of hyperp...
M. Orazov, V. Radzinsky, A. I. Davydov et al.· Voprosy ginekologii akušerst...· 0 citations
Overall, evidence linking BPA exposure to ovarian-cancer-related outcomes remains limited, and current findings do not establish that BPA causes OC or worsens patient prognosis in humans.
Lu-Lu Zhang, Tong Yu, Zhong-Liu Bian et al.· Frontiers in Cell and Develo...· 0 citations
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