Reproduktionsmedizin und Endokrinologie

The Role of Pediatric Andrology Prevention in Reducing Adult Male Infertility

The future of male pediatric fertility preservation is poised for transformative progress. Over the past fifteen years, the world has witnessed a notable decline in birth rates, a phenomenon often referred to as global low fertility or denatality. While social and economic determinants play a significant role, biologic...

Preimplantation genetic testing for male factor infertility: lights and shadows.

Reproduktionsmedizin und Endokrinologie

Conceptual Study of Infertility in Ayurveda W.S.R. to Anovulation

Now a days more and more couples are showing up at fertility clinics around the world, searching for answers, hope and eventual parenthood. Despite the enormous growth in population it should be noted that humans are not very efficient at producing babies. Infertility is a significant global health concern affecting ap...

Genetics of Premature Ovarian Insufficiency: From Molecular Architecture to Precision Medicine

Premature ovarian insufficiency (POI) affects 1–3.7% of women and causes infertility and long-term morbidity. Next-generation sequencing has identified more than 130 POI-associated genes. The diagnostic yield of genetic testing depends on cohort size and the quality and scope of the genetic analysis, reaching 29.3% in...

The role of mitochondrial dysfunction and genetics in female infertility and premature ovarian insufficiency.

BACKGROUND Female infertility occurs in ∼37% of infertile couples, while premature ovarian insufficiency (POI) impacts 1-3.7% of women under the age of 40. POI is clinically heterogeneous, with various genetic pathways associated with its pathogenesis. Mitochondrial diseases (MDs) are a broad group of clinically hetero...