AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
This study reveals distinct plasma metabolic signatures across COPD subgroups categorized by cigarette smoking history, including smokers, ex-smokers, and non-smokers.
Untargeted metabolomics has revealed significant systemic metabolic dysregulation in ILD and the biomarkers and “metabolic-immune-endocrine” interaction patterns identified offer potential leads for early diagnosis and targeted treatment, which require validation in larger cohorts.
Serum levels of five DEMs (Glu, Pro, Orn, Cit, Cit, and Arg) are closely linked to ALD-related metabolic dysregulation; they serve as potential indicators of ALD progression and provide valuable insights for the clinical staging and targeted intervention of ALD.
Alterations in metabolomic profiles of COPD and IPF suggested shared dysregulation of several lipids, however, some metabolites pointed to disease-specific differences.
Serine depletion by increased demands of sphingolipid, and possibly transsulfuration pathway, metabolism is associated with elevations in cytotoxic deoxyceramides and reductions in glycine and methionine availability for one-carbon metabolism, a key marker of residual CVD risk.
Findings highlight coordinated dysregulation of amino acid and lipoprotein metabolism as hallmarks of established MS and identify a novel association of the omega-6/omega-3 ratio with inflammatory disease activity.
Obstructive Sleep Apnea Syndrome (OSAS) is associated with systemic inflammation and immune dysfunction, yet the specific metabolic alterations within immune cells remain poorly understood. In this exploratory study, we characterized the metabolome of peripheral mononuclear cells (PMNCs) from patients with OSAS and hea...
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