TL;DR
The inverse correlation between volume and cognitive impairment suggest a mechanistic relationship and neurogenic orthostatic hypotension is associated with lower locus coeruleus basal forebrain tract volume.
BACKGROUND The thalamus is a core node of the basal ganglia-thalamocortical circuit implicated in Parkinson's disease (PD) and depression. This study examined associations among thalamic volume ratio (TVR), nigrostriatal dopaminergic degeneration, and depressive symptoms in PD. METHODS We included 170 PD patients wit...
Dopaminergic depletion is associated with a targeted SMN reorganization, potentially maintaining network information flow despite progressive hub loss, and whether this reorganization represents compensation or a consequence of progressive pathology requires further longitudinal assessment.
This retrospective cross-sectional study investigated limbic structural alterations across prodromal PD phenotypes defined by rapid eye movement sleep behavior disorder (RBD) and/or hyposmia to reveal phenotype-specific significant covariance patterns involving olfactory-related and Papez circuit regions.
QSM-derived CPcal is a scalable, radiation-free imaging phenotype that complements volumetry by characterizing calcific CP tissue, which is associated with cardiometabolic health, brain aging, and neurodegenerative risk, particularly in the third ventricle.
Lower hippocampal fractional anisotropy in the LBD spectrum relative to HC potentially reflects microstructure alterations; however, higher hippocampal FA in LBD with more severe depression suggests more complex microstructural changes such as altered synaptic density, Lewy neurite organization, or neuroplastic changes...
Background Aortic aneurysms represent significant cardiovascular pathologies with an incompletely understood pathogenesis. The hypothalamus, a critical structure in regulating autonomic functions, endocrine activity, and circadian rhythms, may play a role in this context. Methods We used Mendelian randomization (MR) to...
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