Genomic Characterisation of Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter hormaechei Clinical Isolates from Nigeria: Evidence of Resistance, Virulence, and Putative Plasmid-Mediated Gene Sharing
Sep 2026· Current Microbiology· Vol 83· 0 citations· 46 references
Medicine
TL;DR
Describing clinically relevant resistance and virulence determinants in three purposively selected carbapenem-resistant Enterobacterales from Nigerian tertiary-care hospitals identifies possible plasmid-mediated gene sharing.
The genomic epidemiology and genomic characteristics of clinically significant CRE recovered at University Hospital “Lozenetz”, Sofia, between 2022 and 2025 indicate that ST6260 is an emerging hospital-associated multidrug-resistant lineage.
Emma Keuleyan, I. Stoikov, Theodor Todorov et al.· Acta Microbiologica Hellenic...· 0 citations
These findings provide a comprehensive genomic characterization of CRKP from respiratory tract and bloodstream infections and support genome-based surveillance integrating clonal lineages, capsular types, and plasmid architectures to strengthen infection control and facilitate early identification of emerging high-risk...
Qian Liu, Hong Shen, Xi Chen et al.· Virulence· 0 citations
Carbapenemase-producing Enterobacterales (CPE) pose a significant public health concern due to the limited therapeutic options and increasing dissemination outside clinical settings. Wastewater treatment plants (WWTPs) have been proposed as relevant environmental reservoirs for antimicrobial-resistant bacteria and mobi...
J. P. R. Furlan, Giovanna Carrasco Bueno, Rubens R. Sousa-Carmo et al.· Environmental Monitoring & A...· 0 citations
Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) increasingly combines high-risk clonal expansion, mobile resistance platforms and limited treatment options. We investigated the genomic epidemiology, resistance and virulence architecture, plasmid backbones, and therapeutic vulnerabilities of CRKP circulati...
Arwa Al Rujaibi, Zaaima Al Jabri, Azza Mohammed Al Mamari et al.· Antibiotics· 0 citations
Purpose Carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a major global public health threat due to its high-level antimicrobial resistance and limited therapeutic options. The emergence of CRKP isolates co-harboring multiple carbapenemase genes further complicates clinical management and infection control....
Yao Li, Hai-Jun Li, Xiao-Hong Xu et al.· Infection and Drug Resistanc...· 0 citations
Klebsiella pneumoniae, a WHO-designated critical-priority pathogen, is a predominant cause of neonatal bacteraemia in India, associated with high morbidity and mortality. The global emergence and spread of high-risk clones, combined with convergence of antimicrobial resistance (AMR) and virulence traits, underscores th...
S. N. Sarkar, Abhinandan Mallick, Shravani Mitra et al.· Molecular Biology Reports· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.