TL;DR
The findings indicate that the Alg/PANI/NPs hydrogel is a promising multifunctional biomaterial that supports regenerative responses through immunomodulatory, antioxidative, and cytocompatible effects.
Oxidative stress is a critical barrier to effective bone regeneration, often impairing cellular function and osteogenic differentiation. In this study, we report the novel development of a multifunctional chitosan/collagen (CS/Coll) hydrogel integrated with praseodymium-doped mesoporous bioactive glass nanoparticles (P...
3D-printed polylactic acid scaffolds coated with polydopamine and loaded with CS nanoparticles encapsulating 4-methoxycinnamic acid (MCA), a hydrophobic polyphenolic compound with antioxidant and anti-inflammatory activities offer a robust platform for scaffold-based bone tissue engineering strategies.
Bone defects caused by trauma, degenerative disorders and congenital abnormalities remain a major clinical challenge, necessitating the development of bioactive scaffolds that can promote effective bone regeneration. In this study, a composite scaffold composed of sodium alginate, polyvinyl alcohol and nanocellulose wa...
It is demonstrated that the PCL/Gel/IL-4 membrane synergistically improves physical properties, release behavior, osteogenic capacity, and immunomodulation, offering a promising multi-functional platform for bone regeneration.
In this study, a multifunctional composite hydrogel was developed by combining Sodium Alginate (Alg) with synthesized Poly(propylene glycol) phosphazene (PGP) for infected wound healing. Structural characterizations confirmed successful matrix formation, yielding a tunable macroporous network with excellent swelling ca...
Diabetes-related bone defects are severely inhibited by high-glucose-induced chronic inflammation, oxidative stress, and angiogenesis impairment, resulting in limited repair efficacy of conventional scaffolds in this complex microenvironment. This study constructed a 3D-printed DexMA/P-HAP/Cu₂O@MXene composite scaffold...
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