Impact of strontium- and fluoride-containing mesoporous bioactive glass nanoparticles in dental resin composite

Abstract

This study explores the incorporation of strontium (Sr) and fluoride (F) containing mesoporous bioactive glass nanoparticles (xSr-yF-MBGNs) into dental resin composites to enhance their performance. xSr-yF-MBGNs were synthesised via a microemulsion-assisted sol-gel process with hydrodynamic diameters of 170–200 nm and 8–10 nm pores. Fluoride doping increased the Zeta potential from −33 mV to −58 mV, indicating improved particle stability. Due to their high surface area and porosity, the nanoparticles facilitated controlled ion release, promoting remineralisation and antibacterial effects. xSr-yF-MBGNs formed an apatite-like layer on surfaces without harming periodontal ligament stem cells at 250 µg/mL concentrations. Composites with 5%wt (F1) and 2.5%wt (F2) of Sr-F-MBGNs showed comparable mechanical properties to a commercial nanofilled composite. Remineralisation and ion release of the resin composite improve therapeutic benefits in restorative dentistry. Further research on antibacterial efficacy is recommended to validate these findings and assess the long-term performance of these advanced dental materials.