Synthesis of Novel Pyrazolopyranopyrimidine Acyclic Nucleosides Disubstituted at N2/C5 as Potential Anti-SARS-CoV-2 Inhibitors: Structural Characterization, and In Silico Studies

Ezaddine Irrou Younesse Ait Elmachkouri Rakibul Islam D. Dhaked Y. Riadi P. Mahindrakar M. Geesi A. Altharawi Manal A. Alossaimi Mohamed Labd Taha

Sep 2026 · Journal of Pharmaceutical Innovation · Vol 22 · 0 citations · 115 references

TL;DR

Novel pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine acyclonucleosides bearing HBG-derived pseudosugar moieties bearing HBG-derived pseudosugar moieties as potential antiviral agents targeting key SARS-CoV-2 proteins are designed and synthesized.

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