This review discusses the most recent and relevant SIRT1, mitochondrial and inflammatory-related findings and highlights prominent strategies, such as increasing SIRT1 activity, to promote healthier and longer lives.
Abstract
Simple Summary Aging is the key risk factor for a variety of diseases, such as heart disease, diabetes, and dementia. One of the hallmarks of aging is cellular senescence, a condition where cells stop dividing but remain metabolically active, thus becoming detrimental to the surrounding tissues. This review focuses on a protein known as SIRT1, a molecular guardian of our cells. SIRT1 plays a critical role in maintaining mitochondria health and in suppressing inflammation. Levels of SIRT1 decrease with age, which leads to mitochondrial dysfunction and the release of mitochondrial DNA into the cytoplasm, triggering inflammation. This inflammation further reduces SIRT1 levels, creating a cycle that accelerates cellular aging. This review discusses the most recent and relevant SIRT1, mitochondrial and inflammatory-related findings and highlights prominent strategies, such as increasing SIRT1 activity, to promote healthier and longer lives.
Ageing is an outcome of insufficient maintenance of the internal environment. Over time, each component of the internal environment changes from the molecular level to the organismal level to maintain homeostasis. These changes occur through several biological pathways, such as adenosine monophosphate-activated prote...
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