Oxytocin: A Candidate Biomarker of Health Status During Early Childhood Development

Abstract

The theoretical underpinnings and empirical data supporting oxytocin as a context-dependent biomarker of prosocial affiliation, bonding, attachment, emotional regulation, cognitive development, and the modulation of stress responses are summarized. We propose an interdisciplinary consensus against a backdrop of inconsistencies concerning behavioral and experimental findings for the oxytocinergic system. Current knowledge gaps demonstrating the inability to establish a hierarchy of findings are related to the following: (a) the theory and practice of oxytocinergic therapeutic interventions; (b) identification, characterization, and quantification of functional, mechanistic, and molecular biomarkers and matrices; (c) context- and time-dependent resilience factors associated with mind–brain–body development, (d) measures of intergenerational transmission, and (e) summative indicators of psychopathological co-morbidities. We analyze prospective objective measures of oxytocin against subjective caregiver reports of positive childhood experiences (PCEs, resulting from secure nurturing, established daily routines, pleasurable social interactions, opportunistic and spontaneous play, secure environments), which favor healthy developmental outcomes in preschool children. Few studies prospectively use the painless, noninvasive sampling of risk and resilience biomarker levels to index the health status, emotional regulation, and cognitive development in preschool children. We present the methodology for novel measures of risk (cortisol) and resilience (oxytocin) in human scalp hair. Future studies validating the therapeutic efficacy of oxytocin or the stress-mediating effects of oxytocin on socioemotional regulation and health status should systematically address these gaps.