A role for the metabolic–inflammatory axis in brain vulnerability is supported and preservation of neuroimmune homeostasis may be important for maintaining cognitive health in obesity-associated metabolic disorders.
Aging is associated with increased neuroinflammation and a decrease in neuroplasticity, contributing to cognitive decline and increased risk for neurodegenerative disease. Nutritional interventions, such as walnut supplementation, may counteract these effects due to walnuts' high content of polyunsaturated fatty acids,...
A. Carey, S. Poulose, D. Fisher et al.· Journal of Medicinal Food· 0 citations
Aims: Systemic inflammation driven by lipopolysaccharide (LPS) induces neurobehavioral deficits, hypothalamic-pituitary-adrenal (HPA) axis dysregulation, and neurodegeneration-related alterations. N-acetylcysteine (NAC) is a potent antioxidant with emerging anti-inflammatory properties. This study investigated whether...
M. Öz, D. A. Aslanlar, Hüseyin Erdal et al.· Kastamonu Medical Journal· 0 citations
BACKGROUND
Cerebral palsy (CP) is characterized by persistent motor impairment and may be accompanied by sustained neuroinflammation. Metabolic reprogramming is increasingly recognized as an important regulator of microglial inflammatory responses; however, its involvement in the effects of Tuina remains unclear.
OBJ...
Yanqi Jiang, Dan Wang, Yi-Yun Zhang et al.· Brain Research Bulletin· 0 citations
Midlife obesity is an established independent risk factor for age-related cognitive decline, yet direct causal experimental evidence and underlying gut microbial mechanisms remain poorly defined. Using a mouse model of high-fat diet (HFD)-induced obesity restricted to the midlife period (6–12 months of age) in male wil...
Xiao-Mei Bian, Jia-Qi Cao, An-Rui He et al.· International Journal of Mol...· 0 citations
The growing prevalence of obesity has been associated with metabolic and neurobiological alterations that compromise brain integrity and behavior. Diet-induced obesity, often accompanied by hypercholesterolemia, activates apoptotic signaling pathways in the central nervous system, contributing to cognitive and behavior...
Ítalo Leonardo Diogo, G. A. S. Maia, I. J. P. Garcia et al.· Neurochemical Research· 0 citations
Metabolically associated steatotic liver disease (MASLD) represents a spectrum of liver pathology driven by obesity and metabolic dysregulation. The present study aimed to evaluate the structural and morphological liver changes during MASLD development under experimentally induced obesity. A prospective controlled expe...
Gulchehra Soliyeva, Shakhzoda Abdulazizova· BIO Web of Conferences· 0 citations
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