The available evidence does not support universal biomarker cut-offs or uniform interpretation of PIRA-associated concentrations, and age, BMI, and renal function should be considered when interpreting circulating NfL and GFAP, particularly in studies of progression.
Abstract Objectives Serum neurofilament light chain (sNfL) reflects neuroaxonal injury in relapsing-remitting multiple sclerosis (RRMS), but its clinical utility is limited by high interindividual variability and confounders such as renal function. Population-based thresholds may therefore be suboptimal for longitudina...
S. de las Heras Flórez, Gema García de la Rosa, Vicente Martín García et al.· Clinical Chemistry and Labor...· 1 citation
The longitudinal zNfL changes were related to lesion activity and subsequent atrophy, even after including MRI measures, and cross-sectional zNfL was related to active disease and predictive of disease progression, but not after taking MRI measures into account.
Rozemarijn M. Mattiesing, G. Gentile, M. Battaglini et al.· Journal of Neurology· 0 citations
Baseline UA was not significantly associated with functional decline or survival, and riluzole did not significantly modify the UA–progression association, and Larger multicenter studies with repeated UA measurements are warranted.
Hui-Hong Tian, Nan Hu, Ming Qi et al.· Neurology and Clinical Neuro...· 0 citations
BACKGROUND
The kappa free light chain (κ-FLC) index is widely recognized as an alternative to oligoclonal bands for demonstrating intrathecal immunoglobulin synthesis in multiple sclerosis (MS). However, its prognostic value remains controversial. We investigated whether physiological age-related changes confound κ-FLC...
A. Emekli, Elif Dilsiz, Nuray Sancar et al.· Multiple Sclerosis and Relat...· 0 citations
The association of LGI with incident MS risk and MS-related brain structural measures in a large prospective cohort suggests that peripheral inflammation may serve as a potential marker for identifying individuals at elevated MS risk, warranting further investigation in interventional studies.
Yi-Zhou Cai, Yu-Jia Bao, Yong-Xuan Li et al.· Frontiers in Immunology· 0 citations
