Jul 2026· AIDS Research and Human Retroviruses· pp.
8892229261471606
· 0 citations· 12 references
Medicine
TL;DR
Analysis of HIV-1 samples collected from two male patients in Shenzhen suggested that the recombination between CRF01_AE and CRF07_BC continued to occur in Shenzhen, potentially contributing to the increasing genetic complexity of the local HIV-1 epidemic.
Abstract
Recombination events are a key driver of human immunodeficiency virus type 1 (HIV-1) genetic diversity. In this study, HIV-1 samples were collected from two male patients in Shenzhen, China. Two novel recombinant forms (Ls6449 and Ls16801) derived from CRF01_AE and CRF07_BC were identified, and their near full-length genomes were obtained. Analysis of these two forms suggested that the recombination between CRF01_AE and CRF07_BC continued to occur in Shenzhen, potentially contributing to the increasing genetic complexity of the local HIV-1 epidemic. These findings highlight the need for enhanced molecular surveillance and genotyping targeting key routes, specifically sexual transmission and mobility-associated spread. It is expected to generate precise epidemiological evidence and inform local HIV prevention and control strategies.
The long-term co-circulation of various HIV-1 subtypes and circulating recombinant forms (CRFs) in China has created an environment conducive to viral recombination. This study identified a novel HIV-1 CRF resulting from the recombination of CRF07_BC and CRF55_01B in Xishuangbanna Prefecture, Yunnan Province. Nearly fu...
Min Chen, Hui-chao Chen, Yanling Ma et al.· AIDS Research and Human Retr...· 0 citations
The CRF01_AE recombinant is the dominant HIV strain in Ningxia, characterized by rapid disease progression and imposing a significant local burden. Current prevention strategies, often based on broad subtype classifications, are insufficient to address the distinct transmission dynamics of such specific recombinants. T...
This study reports the first detection of CRF89_BF in Peruvian infants under 18 months of age, highlighting the importance of ongoing molecular surveillance of HIV-1 diversity and antiretroviral resistance mutations to optimize treatment strategies and strengthen HIV control programs.
Dilan Suárez-Agüero, S. Espetia, Carlos Augusto Yábar et al.· Revista Argentina de Microbi...· 0 citations
Heterogeneous ARV drug resistance dynamics indicated that resistance emergence might be shaped by broader epidemiologic and treatment-related factors rather than ongoing clustered transmission, and there is a need for coordinated molecular surveillance and optimized ART strategies across the MENA countries.
Esraa Al-Fraihat, Amal Irshaid, Mohammed Sallam et al.· Viruses· 0 citations
Some evidence of the influence of HDAg mutations in relation to clinical significance is shown, providing insights for further, longitudinal research into HDV-3, a genotype associated with worse clinical progression.
T. P. Roca, Jackson Alves da Silva Queiroz, A. M. Passos-Silva et al.· Archives of Virology· 0 citations
It is demonstrated that the attenuated strain AHFY‐F140 represents a promising vaccine candidate against both NADC30‐like and JXA1‐like PRRSV infections.
Hengjiao Zhang, Jiakai Zhao, Chengxin Zhang et al.· Transboundary and Emerging D...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
