Sep 2026· Frontiers in Digital Health· Vol 8· 28 references
Abstract
Artificial intelligence is increasingly used in connected medical-device systems for physiological-signal classification and continuous monitoring. This paper presents a simulation study of the learning and policy layers of a zero-trust federated-learning framework for Internet of Medical Things (IoMT) devices. The implemented prototype combines federated averaging, Gaussian perturbation of client updates, a device-level trust score, and gradient-magnitude screening of anomalous client updates. This is a simulation study of the federated-learning and zero-trust policy layers; cryptographic, encrypted-transport, and hardware-attestation components are modeled as deployment considerations or overheads and are not implemented as complete physical or protocol-level modules. Using the ECG classification pipeline described in the methodology, we compare centralized training, traditional federated learning, differentially private federated learning, and the proposed zero-trust federated configuration. The proposed ZT-FL configuration is reported at 0.928 accuracy, 0.920 F1-score, and 0.968 AUC. These results support feasibility within the stated simulation scope and do not establish clinical validity, formal end-to-end DP accounting, comprehensive adversarial robustness, regulatory compliance, or post-quantum readiness.
The results indicate that software engineering work practices are chosen opportunistically, adapted and configured to provide value under the constrains imposed by the startup context.
Nicolò Paternoster, Carmine Giardino, M. Unterkalmsteiner et al.· Information and Software Tec...· 394 citations· ⚡54
This state-of-practice investigation was performed using a literature review followed by a multiple-case study approach and presents how inconsistency between managerial strategies and execution can lead to failure by means of a behavioral framework.
Carmine Giardino, Xiaofeng Wang, P. Abrahamsson· International Conference on...· 175 citations· ⚡19
This study conducts a case survey study based on the secondary data of the major pivots happened in 49 software startups, and demonstrates that customer need pivot is the most common among all pivot types.
Sohaib Shahid Bajwa, Xiaofeng Wang, Anh Nguyen-Duc et al.· Empirical Software Engineeri...· 127 citations· ⚡15
It is found that roles of MVPs in startups were not fully aware by entrepreneurs, and entrepreneurs should consider a systematic approach to fully explore the value of MVP, as a multiple facet product (MFP).
Anh Nguyen-Duc, P. Abrahamsson· International Conference on...· 93 citations· ⚡9
It is found that what perceived as biggest challenges by software startups do vary across different life cycle stages, even though its significance decreases when the learning focuses of the startups move from problem to solution and their products mature.
Xiaofeng Wang, Henry Edison, Sohaib Shahid Bajwa et al.· International Conference on...· 62 citations· ⚡6
A comprehensive overview of how enhanced sampling methods are reshaping the field, with a particular focus on the data-driven construction of collective variables, is provided.
Kai Zhu, Enrico Trizio, Jintu Zhang et al.· Chemical Reviews· 58 citations
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