TL;DR
In the MCAO model, ISO reduced infarct volume, lowered MDA levels, and restored GPX4 expression, which were partly reversed by RBM15 overexpression, which were partly reversed by RBM15 overexpression.
BACKGROUND Doxorubicin-induced cardiotoxicity (DIC) poses a substantial threat to the prognosis and survival of cancer patients. Ferroptosis, mediated in part by suppression of the SIRT1/NRF2 pathway, has been identified as a critical mechanism underlying DIC. Isoginkgetin (IGK), a naturally occurring biflavonoid with...
BACKGROUND Microglial ferroptosis is a key risk factor promoting neuroinflammation after ischemic brain injury (IBI). Although Compound 21 (C21) has neuroprotective and anti-inflammatory properties, its role in modulating microglial ferroptosis in IBI remains unexplored. METHODS IBI was induced in C57BL/6 mice via tr...
Cerebral ischemia-reperfusion injury (CIRI) is a leading cause of neurological disability with few effective therapeutic strategies, and ferroptosis has been proven to participate in CIRI progression while its upstream regulatory mechanisms remain poorly defined. Herein, we performed transcriptomic analysis on GSE16207...
Luteolin attenuates hypoxia-induced ferroptosis-associated changes in human brain microvascular endothelial cells by restoring redox homeostasis and is associated with coordinated modulation of the PPARγ/FABP5/ALOX15 pathway.
Mel attenuates acute neonatal HIBD and reduces ferroptosis-associated neuronal injury, potentially involving modulation of the TXNIP/Trx-1/GPX4 pathway.
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