Sep 2026· Diabetes, obesity and metabolism· Vol 28, pp. 11568 - 11577· 0 citations· 19 references
Medicine
TL;DR
In T2DM, LDL-C burden and variability jointly identified patients at greater risk, especially for MI and cardiovascular mortality, especially in younger adults or longer-duration diabetes subgroups.
Abstract
To assess whether threshold‐based low‐density lipoprotein cholesterol (LDL‐C) burden and visit‐to‐visit variability jointly stratify cardiovascular and mortality risk in adults with Type 2 diabetes (T2DM).
High LDL-C levels were associated with increased cardiovascular risk in patients with chronic kidney disease but not in patients with end-stage kidney disease after multivariable adjustment, suggesting stage-specific LDL-C targets are needed to optimize cardiovascular risk management in chronic kidney disease.
N. Heo, Kyungdo Han, Kyu-Na Lee et al.· American Journal of Medicine· 0 citations
Elevated NHHR is independently associated with increased risks of all-cause and cardiovascular mortality in patients with CHD and T2DM, with a clear nonlinear threshold effect.
Niuniu Wang, Xue-Jin Chen, Hao-Ran Li et al.· Medicine· 0 citations
Among adults with CKM stages 0-3, cumNHHR exposure was associated with incident CVD, whereas NHHR change patterns did not show an independent association beyond baseline NHHR, highlighting the potential value of cumNHHR assessment for early CVD risk stratification.
Yi-Ran Gao, Peng Wang, Jia-Lin Lu et al.· Experimental Gerontology· 0 citations
To identify low‐ and high‐risk intervals for major adverse cardiovascular events (MACE) and all‐cause mortality according to lipid ratios in adults with Type 2 diabetes mellitus (T2DM), stratified by sex.
E. Carretero-Anibarro, J. Quesada, Manuel A. Ruiz-Quintero et al.· Diabetes, obesity and metabo...· 0 citations
Low-grade inflammation was associated with MACE and all-cause mortality, independently of classical risk factors, in individuals recently diagnosed with type 2 diabetes and without prevalent CVD.
S. L. Domazet, A. Sharfo, T. Olesen et al.· European Journal of Preventi...· 0 citations
Background Cardiovascular disease (CVD) remains the leading cause of death worldwide, particularly among older adults. The glycated hemoglobin A1c-to-high-density lipoprotein cholesterol (HbA1c/HDL-C) ratio is an emerging biomarker reflecting glucolipid metabolic derangement. However, prospective evidence regarding its...
Jin Peng, Liu-Rong Yang, Qian Zhang et al.· Frontiers in Public Health· 0 citations
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