BDE47 exposure in lung adenocarcinoma: prognostic biomarkers, immune dysregulation, and mechanistic insights from toxicogenomic and docking studies

Aug 2026

ADRB2 Modulates Asbestos-Induced Pleural Mesothelioma Progression by Influencing IL-17/NF-κB-Related Inflammatory Signalling: An Integrated Network Toxicology, Multi-Omics and Experimental Study.

Findings identify ADRB2 as a potential diagnostic and mechanistic target in asbestos-related PM and suggest that ADRB2 may contribute to crocidolite-induced malignant progression by modulating cellular responses associated with IL-17/NF-κB-related inflammatory signalling.

Shaoyang Huang, Dandan Gu, Jin-Tao He et al. · Chemico-Biological Interacti... · 0 citations

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Open access Aug 2026

Exploratory Toxicogenomic Profiling Identifies Candidate DINCH-Responsive Genes Relevant to Prostate Cancer

Diisononyl cyclohexane-1,2-dicarboxylate (DINCH), a non-phthalate plasticizer adopted as a safer alternative for food-contact and medical-grade materials, is ubiquitously detected in human biomonitoring studies. Despite widespread exposure, its transcriptional effects in prostate cells and the potential prostate cancer...

Chi-Fen Chang, Wen-Hsin Lin, Chao-Yuan Huang et al. · International Journal of Mol... · 0 citations

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Open access Jul 2026

Toxicogenomic Characterization of Common Genes and Signaling Pathways Associated with Multiple Toxic Metal(loid)s in Lung Cancer: A Comparative Analysis of Small-Cell and Non-Small-Cell Lung Cancer

Several genes and signaling pathways implicated in biological processes relevant to lung cancer, including cell survival, inflammation, oxidative stress, and angiogenesis were identified and predicted molecular interaction networks and enriched pathways differed between lung cancer subtypes, underscoring the biological...

K. Živančević, Kıvanç Kok · Cancers · 0 citations

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Open access Aug 2026

Chronic Monobutyl Phthalate Exposure Promotes Anaplastic Thyroid Cancer Progression Through Inflammatory Signaling Dysregulation: Integrated Transcriptomic and Network Toxicology Analyses

Background/Objectives: Chronic exposure to endocrine-disrupting chemicals has been increasingly recognized as a potential contributor to cancer progression. Monobutyl phthalate (MBP), a major metabolite of dibutyl phthalate, is widely detected in human biological samples, yet its long-term impact on anaplastic thyroid...

Yu Deng, Songwei Tan, Jinlan Wei et al. · Biomedicines · 0 citations

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Open access Aug 2026

Prognostic and immunological value of LINC01615-related genes in kidney clear cell carcinoma

The developed risk model offers valuable insights for clinical prognostic prediction and immunotherapy in KIRC and indicates an increased likelihood of immune escape in the high-risk group.

Shi-Bin Guo, Shuangqin Xu, Peng Song et al. · Medicine · 0 citations

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Aug 2026

From Environmental Lead Exposure to Colorectal Cancer: Integrated Transcriptomic and Genetic Analyses Identify HMOX1 as a Prioritized Candidate.

The results suggest that the crude epidemiologic association between blood lead and CRC prevalence is sensitive to covariate adjustment and generate testable hypotheses implicating HMOX1 for future experimental validation.

Ling Wang, Yuning Qin, Weizheng Wang et al. · Biological Trace Element Res... · 0 citations

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