Aug 2026· Reproductive Sciences· Vol 33, pp. 1674 - 1686· 0 citations· 49 references
Medicine
TL;DR
This study elucidates potential molecular links between BPA exposure and GDM, highlighting immune-metabolic dysregulation and identified core genes that may serve as biomarkers or therapeutic targets, thereby advancing precision environmental health strategies for pregnancy.
A hypothesis-generating framework for understanding possible molecular links between environmental contaminants and hepatocarcinogenesis is provided, but does not establish causality or confirm actual TDCPP exposure in the analyzed patient cohorts.
Functional enrichment analysis indicates that BPA-induced NAFLD and OA comorbidity pathways are enriched in muscle cell proliferation, DNA metabolism, and inflammation pathways, indicating that limiting BPA exposure or modulating the RHOB pathway represents a viable approach for intervening in related diseases.
Three central apoptosis-related genes are identified as pivotal genes bridging psoriasis and IBD through apoptosis-related mechanisms, shed light on the shared molecular underpinnings of these comorbid conditions and highlight potential targets for future therapeutic strategies.
Qing Wei, Zhen-Qi Huang, Shao-Zhang Hou et al.· Indian Journal of Dermatolog...· 0 citations
The findings support the involvement of VEI-related molecular alterations in GDM but should be regarded as hypothesis-generating, requiring further validation in larger clinical cohorts and experimental models.
Yue-Ping Wang, Wei-Wei Feng· Current Medicinal Chemistry· 0 citations
BPA-induced CXCL8 upregulation is associated with CRC malignant progression and enhanced p38 MAPK signaling, and TEAD4 may function as an upstream transcriptional regulator of CXCL8, although its direct regulation by BPA remains unclear.
It is suggested that TBPH may be associated with high-fat diet–induced atherosclerosis progression through the dysregulation of key mediators, providing insight into environmental pollutant–driven disease development.
Hui-Chao Pan, Dong Wang, Sheng-Guang Chen et al.· Frontiers in Pharmacology· 0 citations
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