Skip to content

Integrative Multi-Omics Analysis Identifies Key Molecular Targets Linking Bisphenol A Exposure to Gestational Diabetes Mellitus

Aug 2026 · Reproductive Sciences · Vol 33, pp. 1674 - 1686 · 0 citations · 49 references
Medicine

TL;DR

This study elucidates potential molecular links between BPA exposure and GDM, highlighting immune-metabolic dysregulation and identified core genes that may serve as biomarkers or therapeutic targets, thereby advancing precision environmental health strategies for pregnancy.

View source

Similar papers

Open access Jul 2026

Multi-omics and network toxicology prioritize ADAMTS13 as a candidate gene computationally linked to TDCPP targets in hepatocellular carcinoma.

A hypothesis-generating framework for understanding possible molecular links between environmental contaminants and hepatocarcinogenesis is provided, but does not establish causality or confirm actual TDCPP exposure in the analyzed patient cohorts.

Xin Liu, Da-Cai Gong, Tian-Tian Gou et al. · 0 citations
Open access Jul 2026

Bisphenol A drives the comorbidity of non-alcoholic fatty liver disease and osteoarthritis by targeting RHOB: Integrated multi-omics, single-cell analysis, and experimental validation.

Functional enrichment analysis indicates that BPA-induced NAFLD and OA comorbidity pathways are enriched in muscle cell proliferation, DNA metabolism, and inflammation pathways, indicating that limiting BPA exposure or modulating the RHOB pathway represents a viable approach for intervening in related diseases.

Jing-Kai Di, Shuang Wang, Zijian Guo et al. · 0 citations
Open access Aug 2026

Bioinformatics Analysis Identifies Apoptosis Gene Biomarkers Linking Psoriasis and Inflammatory Bowel Disease Comorbidity

Three central apoptosis-related genes are identified as pivotal genes bridging psoriasis and IBD through apoptosis-related mechanisms, shed light on the shared molecular underpinnings of these comorbid conditions and highlight potential targets for future therapeutic strategies.

Qing Wei, Zhen-Qi Huang, Shao-Zhang Hou et al. · 0 citations
Aug 2026

Bisphenol A promotes colorectal cancer malignancy through CXCL8 upregulation associated with p38 MAPK activation: A potential link to type 2 diabetes mellitus comorbidity.

BPA-induced CXCL8 upregulation is associated with CRC malignant progression and enhanced p38 MAPK signaling, and TEAD4 may function as an upstream transcriptional regulator of CXCL8, although its direct regulation by BPA remains unclear.

Wei Ao, Hao-Ran Li, Yuhong Zhang et al. · 0 citations
Open access Aug 2026

Association between TBPH exposure, increased MMP9 expression, and atherosclerosis: evidence from integrated network analysis and in vivo experiments

It is suggested that TBPH may be associated with high-fat diet–induced atherosclerosis progression through the dysregulation of key mediators, providing insight into environmental pollutant–driven disease development.

Hui-Chao Pan, Dong Wang, Sheng-Guang Chen et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.