GX_P2V-mBJ-N, a recombinant coronavirus in which the bright green fluorescent protein mBaoJin is fused to the nucleocapsid (N) protein, provides a simple and reliable tool for coronavirus tracing, immune surveillance, and antiviral drug evaluation.
ABSTRACT Climate change has expanded the range of vectors for the chikungunya virus (CHIKV), thereby increasing its global threat. This situation underscores the urgent need for antiviral therapies. However, the development of drugs is limited by the need for Biosafety Level 3 (BSL-3) containment and the lack of tools...
Mengyuan Zheng, Zhouling Pan, Yanxiang Jiang et al.· Journal of Virology· 0 citations
Objective: The Baculovirus Expression Vector System (BEVS) is an established eukaryotic platform for high-yield recombinant protein production and is widely utilized for generating vaccine antigens, including recombinant classical swine fever virus E2 glycoprotein, African swine fever virus structural proteins (p72, p3...
Beginda Ridwan, F. P. Salmanida, Rika Wahyuningtyas et al.· Vaccines· 0 citations
Mpox is a re-emerging viral disease that has raised global public health concerns, highlighting the need for rapid antibody production and diagnostic development platforms. This study aimed to develop and evaluate a plant-based transient expression system for the production of Mpox virus-specific monoclonal antibodies,...
The feasibility of developing a PRRSV DIVA vaccine through targeted modification of an N protein epitope is demonstrated, providing a potential strategy to facilitate PRRS control and suggests that combining the recombinant virus with cELISA diagnostic tests allows accurate differentiation between vaccinated and wild-t...
Ji-Wen Sun, Jian Wang, Kun Li et al.· Journal of Virology· 0 citations
Findings identify spirostane saponins as promising antiviral scaffolds as promising antiviral scaffolds and support their further development as broad-spectrum antiviral agents.
E. Jiménez-Posada, O. M. Mosquera-Martínez, Sara M. Robledo et al.· Drug development research (P...· 0 citations
A previously unrecognized mechanism by which a highly pathogenic feline coronavirus circumvents host RNA restriction is revealed and new insight is provided into FIPV–host interactions that may inform future studies of RNA-level counter-restriction mechanisms in other animal and human coronaviruses.
Miao Zhang, Na Li, Kelimujiang Aishanjiang et al.· PLoS Pathogens· 0 citations
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