Overall, curcumin appears to be a promising adjunctive candidate for limiting secondary injury after SCI, but further mechanistic clarification and improved delivery strategies will be required to enhance translational relevance and support future clinical application.
Spinal cord injury (SCI) triggers a complex and evolving cascade of pathological events in which neuroinflammation and microenvironmental imbalance critically constrain repair. Among the cellular mediators, microglia exhibit remarkable functional plasticity, transitioning across diverse states that can either support t...
Zi-Yue Ma, Zi-Cheng Lu, Zi-Peng Zhou et al.· International Journal of Mol...· 0 citations
Caspase-1 is a central mediator of canonical inflammasome signaling and drives neuroinflammatory injury through interleukin-1β (IL-1β) and interleukin-18 (IL-18) maturation, gasdermin D (GSDMD)-mediated pyroptosis, and secondary inflammatory cascades. In spinal cord injury (SCI) and other neurologic disorders, experime...
Adonicah Y. Cummings, Adham M. Khalafallah, Bhavjeet S. Sanghera et al.· International Journal of Mol...· 0 citations
The interplay between ferroptosis and neuroinflammation during secondary injury after spinal cord injury (SCI) critically drives permanent neurological dysfunction. Targeting both processes simultaneously is a promising therapeutic strategy. Tetramethylpyrazine (TMP), the main active component of Ligusticum chuanxiong,...
Spinal cord injury (SCI) represents a profoundly serious neurological disorder characterized by limited self-repair capabilities and accompanied by secondary inflammatory damage, rendering its treatment a pressing challenge in the field of medical science research. During the acute phase of SCI, the expression levels o...
Xiang-Zi Wang, Xiao-Quan Liang, Yu-Qi Lin et al.· Journal of Neuroimmune Pharm...· 0 citations
BACKGROUND
Hypoxic-Ischemic Encephalopathy (HIE) is a severe neonatal neurological disorder, in which oxidative stress serves as a central mediator of brain injury. Paeonol (Pae), a phenolic compound with established anti-inflammatory and antioxidant properties, remains underexplored as a therapeutic strategy for HIE....
Ding-Wang Hu, Jiang-Han Li, Ling-Bin Ye et al.· European Journal of Pharmaco...· 0 citations
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