Quercetin-loaded invasomal gel: preparation, optimization, in vitro evaluation and ex vivo skin permeation evaluation

Development and Optimization of Baicalin-Loaded Transniosomes Using Quality by Design: Dermatokinetic and In Vivo Efficacy Evaluation.

OBJECTIVE This study aimed to develop and optimize a baicalin-loaded transniosomal gel (BCL-TN) to enhance the dermal delivery and therapeutic efficacy of baicalin for the management of skin cancer. SIGNIFICANCE Baicalin possesses potent anticancer activity but exhibits poor skin permeability, which limits its clinic...

Formulation and Evaluation of Phloretin-Loaded Functionalized Invasomes for Targeted Breast Cancer Therapy

Doxorubicin-Postbiotic Transethosomes: Formulation and In Vitro Evaluation

The developed transethosomal system showed favorable physicochemical properties, sustained drug release, stability, antioxidant and antimicrobial activity, and significant cytotoxicity against melanoma cells, which support its potential as a multifunctional topical platform for localized melanoma therapy and provide a...

Design, Development, and Characterization of Luliconazole-loaded Bilosomal Gel for Enhanced Cutaneous Delivery

Findings support the LZ-loaded bilosomal gel as a controlled topical delivery system and support further evaluation of the LZ-loaded bilosomal gel.

Development and Evaluation of a Hydroxyurea-loaded Invasome Hydrogel for Enhanced Anti-psoriatic Efficacy and Reduced Systemic Exposure

Formulation and Characterization of Lipidic Vesicles Utilizing CCD for Enhanced Permeation of Phenylephrine HCl for Prevention of CIA.

INTRODUCTION Chemotherapy-induced alopecia (CIA) is a common and distressing side effect of cancer therapy. Phenylephrine hydrochloride can reduce follicular exposure to chemotherapeutic drugs through localized vasoconstriction, but its topical effectiveness is limited by poor skin penetration. Invasomal nanocarriers p...