Aug 2026· Journal of Molecular Neuroscience· Vol 76· 1 citation· 114 references
Medicine
TL;DR
By integrating recent advances in purinergic, redox, and neuroimmune signaling, this review provides a heuristic framework for understanding context-dependent P2X7 activation while distinguishing established mechanisms from emerging concepts that require further experimental validation.
Neuroinflammation and metabolic dysfunction converge in diverse neurological disorders, yet the molecular mechanisms linking these processes remain incompletely defined. This review integrates current evidence that the lipocalin-2 (LCN2) - pyruvate dehydrogenase kinase (PDK) axis represents a candidate mechanistic path...
Neuroimmune interactions reveal that the central nervous system (CNS) is dynamically integrated with peripheral immunity. This bidirectional communication is mediated by microglia, astrocytes, peripheral immune cells, and the neurovascular unit through cytokines, chemokines, complement proteins, neurotransmitters, and...
Ischemic stroke is characterized by a complex interplay between neuroinflammation, oxidative stress, and vascular dysfunction, ultimately leading to disruption of the neurovascular unit and impaired tissue recovery. While microglial activation is a central driver of postischemic inflammation, increasing evidence indi...
Overall, this Collection positions mitochondrial biology as a mechanistic framework connecting metabolic dysfunction, cellular stress, neuroinflammation, and neuronal degeneration, and supports its development as a therapeutic target for disease-modifying interventions in neurological disorders.
Rita Valenzuela, A. I. Rodriguez-Perez· Cellular and molecular neuro...· 0 citations
Highlights What are the main findings? NRG1 emerges as a context-dependent regulator of neuroinflammation that coordinates microglial, astrocytic, oligodendroglial, neuronal, and neurovascular responses through ErbB receptor signaling rather than functioning as a uniformly anti-inflammatory molecule. Across multiple pr...
Gregory D. Ford, Christopher McGinley, Oluwafayokemi Oyolola et al.· Cells· 0 citations
Alzheimer's disease (AD) is characterized not only by amyloid-β and tau pathology but also by progressive failure of multicellular homeostasis. The P2X7 receptor (P2X7R), a low-affinity ATP-gated ion channel preferentially activated in extracellular ATP-rich pathological microenvironments, is well positioned to transla...
