Serum miR-369-3p Downregulation Correlates with Poor Prognosis in Acute Ischemic Stroke and Mitigates Endothelial Injury by Targeting VAV3

Predictive Value of Abnormal Expression of miR-378a-3p in Elderly Stroke Patients for Cognitive Impairment After Stroke.

BackgroundPost-stroke cognitive impairment (PSCI) plays an important role in recovery and quality of life in elderly stroke patients. MicroRNAs play critical roles in the pathophysiology of PSCI.PurposeThe expression of miR-378a-3p in elderly stroke patients and its potential as a predictive biomarker for PSCI was expl...

LINC01094/miR-128-3p axis-mediated regulation of neuronal apoptosis and inflammation in post-intracerebral hemorrhage brain injury

miR-130a-3p Exacerbates Sepsis-Induced Cardiac Dysfunction by Promoting Inflammation and Targeting PDK4

Background Sepsis is frequently complicated by systemic inflammatory injury and cardiac dysfunction, which serve as risk factors of adverse clinical outcomes and increased mortality risk. To clarify the function of miR-130a-3p in sepsis diagnosis and its regulatory role in sepsis-induced inflammatory injury and cardiac...

Study on the Expression of MiR-642b-3p in Spontaneous Intracerebral Hemorrhage and Its Regulatory Mechanism on Endothelial Cell Injury

MiR-642b-3p is upregulated in sICH and mediates thrombin-induced endothelial cell injury, at least in part, by targeting CCNA2.

Protective effect of miR-642b-3p against brain injury after intracerebral hemorrhage by targeting SERPINE1.

The findings support that restoration of miR-642b-3p alleviates post-ICH cerebral edema and neurological deficits via targeted inhibition of SERPINE1-mediated inflammation, involving suppression of NLRP3 inflammasome and promotion of M2 polarization.

Clinical value and regulatory role of miR-4446-3p in coronary heart disease

Coronary heart disease (CHD) poses a major threat to global health due to its high incidence and mortality. This study aims to investigate the role of miR-4446-3p in CHD and its potential regulatory mechanisms. The research enrolled 103 CHD patients and 91 healthy volunteers (HV). CHD patients were stratified into MACE...