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Review Open access Sep 2026

Resting-State Functional Connectivity Alterations in Insomnia Disorder: A Systematic Review of Studies Published from 2020 to July 2025

The overall pattern is compatible with hyperarousal, but both increased and decreased connectivity were reported; diagnostic definitions, sex, symptom severity and duration, medication exposure, acquisition conditions, and seed-based versus data-driven analyses may moderate direction and magnitude.

Ya-Ni Zhang, Yi-Wen Zhang, Cai-Li Shi et al. · 0 citations
Open access Sep 2026

Insula-cerebellar functional connectivity associated with somatic symptoms in mood disorders: Differential patterns and longitudinal evidence in major depressive disorder.

AIM This study aimed to identify the resting-state functional connectivity (rsFC) of insula subregions associated with nonspecific somatic symptoms in mood disorders and to examine whether these connections are state-dependent. METHODS In Phase 1, seed-based rsFC analyses were performed using 12 insula subregions fro...

Shin Hattori, T. Kamishikiryo, Alan S. R. Fermin et al. · 0 citations
Open access Sep 2026

306. Genetic and neuroimaging correlates of symptom severity in major depressive disorder: an imaging–genetics study

Abstract Background The habenula is a key region involved in mood and sleep regulation and is critically implicated in major depressive disorder (MDD). Aims & Objectives This imaging–genetics study aimed to characterize the relationships among genetic variation, habenula-centered brain connectivity, and clinical featur...

M. Kim, J.-Y. Jung, S.-J. Cho et al. · 0 citations
Sep 2026

Cerebellar Alteration in Resting-State Functional Connectivity Among Kratom (Mitragyna speciosa) Users: Insights from Functional MRI.

Chronic kratom consumption may alter brain activity, especially in areas linked to the DMN, cognition, and reward processing, and enhanced FC between salience and cerebellar networks may reflect compensatory mechanisms or adaptations to kratom's effects.

Suzana Mat Isa, A. A. Abd Hamid, Muhamad Zabidi Ahmad et al. · 0 citations
Review Open access Aug 2026

Neuroimaging Correlates of Pain in Parkinson's Disease: A Systematic Review of Structural and Resting-State fMRI Studies.

Chronic pain is a common non-motor symptom in Parkinson's disease (PD), but its central neural mechanisms are not fully understood. Structural and resting-state functional MRI offer non-invasive insights into brain structural and functional correlates of pain. This systematic review synthesizes neuroimaging evidence on...

S. S. Msigwa, Given Kihaga, Qiu-Yan Yu et al. · 0 citations
Review Open access Sep 2026

Functional brain abnormalities in panic disorder: A systematic review of functional magnetic resonance imaging studies.

Panic disorder (PD) is a psychiatric condition marked by recurring, unexpected panic attacks characterized by intense fear and rapid-onset physiological symptoms. Functional magnetic resonance imaging (fMRI) in individuals with PD has revealed abnormalities in several brain regions associated with fear processing, emot...

Saba Mehrtabar, Atra Ajdari, Anahita Azinfar et al. · 0 citations

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