Open access
Enhancing early Alzheimer's disease clinical trials through prognostic score covariate adjustment
B. T. Scodari
Roland Brown
Xiao-Tong Jiang
Chang-Yu Shen
Kyle Ferber
Shuang Wu
Feng Gao
Szofia Bullain
B. Millen
Medicine
Abstract
A prognostic score (PS) summarizes a patient's expected disease progression and can increase the statistical efficiency of clinical trials when included as an analysis covariate.