Dapagliflozin attenuates methotrexate-induced hepatorenal toxicity in rats: insights into oxidative stress, inflammation, autophagy and apoptosis.

Losartan inhibits methotrexate-induced testicular damage via anti-inflammatory and anti-apoptotic effects.

It is demonstrated that AT1R inhibition using Losartan successfully mitigates MTX-induced testicular damage by addressing this upstream mechanistic pathway and Losartan has been identified as a viable treatment strategy for preserving male reproductive function following cytotoxic therapy.

Piribedil attenuates methotrexate-induced nephrotoxicity in rats: associated changes in miR-205/EGLN2, Nrf2, and PERK/ATF4/CHOP-related stress responses.

Hepatoprotective Effects of Dulaglutide against Methotrexate-Induced Liver Injury in Rats

Background and Objectives: The cellular antioxidant defense system is disrupted, which results in hepatotoxicity. When the antioxidant defence system is weakened, hepatocyte oxidative damage results from an increase in reactive oxygen radicals. The chemotherapeutic and immunosuppressive drug methotrexate (MTX) is often...

Involvement of NOD1/NF-κB/MAPK pathway in the protective effect of procyanidin B2 against methotrexate-induced nephrotoxicity

Objective Methotrexate (MTX) is a very effective agent used to treat rheumatoid arthritis and malignant diseases. Despite its usefulness, the long-term use of MTX is associated with multiorgan toxicities, including kidney injury. Thus, there is a necessity to explore a renoprotective agent with low side effects. Procya...

Ferulic acid abrogates methotrexate-induced pulmonary injury by reducing inflammation and endoplasmic reticulum stress in rats.

Background The methotrexate (MTX) is employed in the treatment of various malignancies, including breast cancer and lymphoma, as well as chronic inflammatory diseases, but high doses can cause pulmonotoxicity. Ferulic acid (FEA) is a phenolic compound that has become a promising candidate for oxidative stress (OS) rela...

Empagliflozin shields brain from methotrexate toxicity: Nrf2/HO-1/GPX4 activation prevents ferroptosis and chemo-brain in rats.

BACKGROUND Methotrexate (MTX) can induce "chemo-brain," but mechanisms remain incompletely defined. Ferroptosis has been implicated in MTX toxicity. We investigated whether Empagliflozin (EMPA) protects against MTX-induced neurotoxicity by modulating ferroptosis-related pathways. METHODS Male Sprague-Dawley rats (n =...