Dual knockdown of Scn1b and Gsdmd induces an M2-like functional state in macrophages and modulates inflammation and fibrosis in a rat model of acute respiratory distress syndrome

V. Kiseleva P. Vishnyakova Anna Kosyreva E. Karpulevich I. Tsvetkov Ольга Андреевна Машкова Maria Kuznetsova Aida Bagdasarian V. Karyagina I. Kiselev A. Lokhonina Anastasiya D. Bogoyavlenskaya D. Kudryavtsev I. Arutyunyan A. Soboleva A. Ryabova A. Elchaninov G. Sukhikh T. Fatkhudinov

Aug 2026 · Molecular Biology Reports · Vol 53 · 0 citations · 41 references

Medicine

TL;DR

The potential use of adoptive transfer of siRNA-modified macrophages to influence the progression of ARDS is investigated and dual knockdown of Scn1b and Gsdmd leads to the formation of an M2-like macrophage phenotype in vitro.

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