Skip to content

Similar papers

Aug 2026

Post-translational chemical modification of E3 ligase for efficient target protein degradation.

This work reports the first ligand-directed chemical strategy that converts transient PROTAC-mediated ternary complex formation into binary target recognition via post-translational chemical modification of an E3 ligase, and believes it could provide a platform for next-generation targeted protein degraders to overcome...

Eunbin Park, Jinjoo Jung, G. J. Kumar et al. · 0 citations
Open access Jul 2026

A tailored CoA ligase–N-acyltransferase cascade for on-DNA amide bond formation gives access to broad substrate scope

DNA-encoded chemical library (DEL) technology is a powerful tool in early-stage drug discovery. Although widely applied in industry and academia, challenges persist in generating DELs with high quality and chemical diversity. Low yields in building-block incorporation, limited selectivity and, most importantly, DNA dam...

Daniel Schaub, Alice Lessing, Fabian Meyer et al. · 1 citation
Jul 2026

Overcoming catalytic barriers to reprogram acyltransferases for bis(2-hydroxyethyl) terephthalate hydrolysis.

The extensive use of polyethylene terephthalate (PET) has resulted in severe environmental pollution and ecological stress. Despite advances in PET recycling, current processes struggle to achieve high product value, as the complete conversion to terephthalic acid remains energetically demanding and economically ineffi...

Jie Qiao, Yibo Song, Nan Zhao et al. · 0 citations
Open access Aug 2026

Improved Purification of sgRNA and pegRNA by Use of a 5’-Terminal Dioctyloxytrityl (DOT) Protecting Group

DOT chemistry is analogous to “DMT-ON” approaches that are well known and widely used in the field, and is fully compatible with existing synthesis workflows, but dramatically improves HPLC purification relative to DMT-ON approaches by providing higher retention and thus better resolution to enable the purification of...

Atish Wagh, Jonathan K. Watts · 0 citations
Open access Aug 2026

Directed Evolution of a Highly Selective Fungal Peroxygenase for the Synthesis of Indigo

The large-scale production of indigo, a widely used textile dye, currently relies on chemical processes that consume non-renewable resources and that generate toxic waste, although biocatalysis is emerging as an environmentally friendly alternative. Here, an unspecific peroxygenase from the fungus Daldinia sp. EC12 (...

Alejandro Beltrán-Nogal, Ivan Mateljak, Dianelis T. Monterrey et al. · 0 citations
Open access Aug 2026

Sequence-guided engineering of a bacterial diterpene synthase induces further cyclization

Enzyme engineering serves as a powerful tool in biocatalysis, enabling the development of enzymes with improved stability, activity, and specificity for a range of academic, industrial, and pharmaceutical applications. However, a limited understanding of sequence–structure–function relationships in terpene synthases, t...

Xiuting Wei, Wenbo Ning, Pin-Shuo Huang et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.