This work reports the first ligand-directed chemical strategy that converts transient PROTAC-mediated ternary complex formation into binary target recognition via post-translational chemical modification of an E3 ligase, and believes it could provide a platform for next-generation targeted protein degraders to overcome...
Eunbin Park, Jinjoo Jung, G. J. Kumar et al.· Bioorganic chemistry (Print)· 0 citations
DNA-encoded chemical library (DEL) technology is a powerful tool in early-stage drug discovery. Although widely applied in industry and academia, challenges persist in generating DELs with high quality and chemical diversity. Low yields in building-block incorporation, limited selectivity and, most importantly, DNA dam...
Daniel Schaub, Alice Lessing, Fabian Meyer et al.· Nature Catalysis· 1 citation
The extensive use of polyethylene terephthalate (PET) has resulted in severe environmental pollution and ecological stress. Despite advances in PET recycling, current processes struggle to achieve high product value, as the complete conversion to terephthalic acid remains energetically demanding and economically ineffi...
Jie Qiao, Yibo Song, Nan Zhao et al.· Bioresource Technology· 0 citations
DOT chemistry is analogous to “DMT-ON” approaches that are well known and widely used in the field, and is fully compatible with existing synthesis workflows, but dramatically improves HPLC purification relative to DMT-ON approaches by providing higher retention and thus better resolution to enable the purification of...
Atish Wagh, Jonathan K. Watts· Journal of Organic Chemistry· 0 citations
The large-scale production of indigo, a widely used textile dye, currently relies on chemical processes that consume non-renewable resources and that generate toxic waste, although biocatalysis is emerging as an environmentally friendly alternative. Here, an unspecific peroxygenase from the fungus Daldinia sp. EC12 (...
Alejandro Beltrán-Nogal, Ivan Mateljak, Dianelis T. Monterrey et al.· ACS Sustainable Chemistry &a...· 0 citations
Enzyme engineering serves as a powerful tool in biocatalysis, enabling the development of enzymes with improved stability, activity, and specificity for a range of academic, industrial, and pharmaceutical applications. However, a limited understanding of sequence–structure–function relationships in terpene synthases, t...