Exolide A, structurally diverse Ent-18-norbeyerane diterpenoid from the stems of Indian mangrove plant, Excoecaria agallocha Linn.
H. Patel
Umme Ummarah Fariha
Sravani Mekala
Kalyani Yamjala
Kiran Munipalle
Bolatito Olanipekun Eunice
M. G. Ponnapalli
Medicine
Abstract
Exolide A (1), a novel ent-18-norbeyerane diterpenoid possessing a hexacarbocyclic framework, 7/5/6/6/5/3 along with four known terpenoids (2-5) were isolated from the chloroform extract of the stems of Excoecaria agallocha. The structure of 1 was elucidated by comprehensive spectroscopic data analysis (IR, HRESIMS, 1H, 13C NMR, DEPT, HSQC, HMBC, 1H1H COSY, 1H1H NOESY), chemical methods, and biogenetic considerations. Compound 2 exhibited a potent α-glucosidase inhibitory activity (IC50 0.11 μg/mL) compared to acarbose (IC50 1.44 μg/mL).