Aug 2026· Proceedings of the 32nd ACM SIGKDD Conference on Knowledge Discovery and Data Mining V.2· pp. 10162-10173· 0 citations· 13 references
Abstract
The deployment of Large Language Models (LLMs) in high-stakes clinical settings demands rigorous and reliable evaluation. However, existing medical benchmarks remain static, suffering from two critical limitations: (1) data contamination, where test sets inadvertently leak into training corpora, leading to inflated performance estimates; and (2) temporal misalignment, failing to capture the rapid evolution of medical knowledge. Furthermore, current evaluation metrics for open-ended clinical reasoning often rely on either shallow lexical overlap (e.g., ROUGE) or subjective LLM-as-a-Judge scoring, both inadequate for verifying clinical correctness. % To bridge these gaps, we introduce LiveMedBench, a continuously updated, contamination-limited, and rubric-based benchmark that weekly harvests real-world clinical cases from online medical communities, ensuring strict temporal separation from model training data. We propose a Multi-Agent Clinical Curation Framework that filters raw data noise and validates clinical integrity against evidence-based medical principles. For evaluation, we develop an Automated Rubric-based Evaluation Framework that decomposes physician responses into granular, case-specific criteria, achieving substantially stronger alignment with expert physicians than LLM-as-a-Judge. % To date, LiveMedBench comprises 2,756 real-world cases spanning 38 medical specialties and two languages, paired with 16,702 unique evaluation criteria. Extensive evaluation of 38 LLMs reveals that even the best-performing model achieves only 39.2%, and 84% of models exhibit performance degradation on post-cutoff cases, confirming pervasive data contamination risks. Error analysis further identifies contextual application---not factual knowledge---as the dominant bottleneck, with 35-48% of failures stemming from the inability to tailor medical knowledge to patient-specific constraints. The code and data are available at https://github.com/ZhilingYan/LiveMedBench/ LiveMedBench.
A Multi-Agent Clinical Curation Framework that filters raw data noise and validates clinical integrity against evidence-based medical principles and develops an Automated Rubric-based Evaluation Framework that decomposes physician responses into granular, case-specific criteria, achieving substantially stronger alignme...
Zhiling Yan, D. Song, Zhen Fang et al.· Proceedings of the 32nd ACM...· 10 citations· ⚡2
SynTrustBench is introduced, an evidence-gated and executable benchmark for evaluating trustworthiness claims across five non-compensable dimensions: fidelity, clinical utility/validity, privacy, equity, and robustness/generalization.
A Dynamic, Automatic and Systematic red-teaming audit framework that continuously stress-tests LLMs for health across four safety-critical axes: robustness, privacy, bias and hallucination, which provides a scalable framework for surfacing latent risks before such systems are deployed in consumer-facing health assistan...
Jiazhen Pan, Bailiang Jian, Paul Hager et al.· Nature Health· 0 citations
A comprehensive framework for transforming LLMs into trustworthy medical specialists is presented, and the evolution toward agentic AI systems that orchestrate them for autonomous, collaborative clinical decision-making is explored.
Kiduk Kim, Jeong Min Song, Dong Yeong Kim et al.· Cell Reports Medicine· 0 citations
Findings show that clinical LLM explainability has shifted toward fluent generative rationales, but evidence that such explanations reflect model reasoning remains limited, and three regulatory priorities are highlighted: prioritizing explanations that enable independent verification or logic auditing over plausibility...
VITA's advantages in accuracy and completeness persisted under the neutral judge; its communication scores were lower, and this results indicate that a purpose-built clinical RAG system remains competitive with frontier LLMs on an open benchmark, consistent with corpus specificity as a design variable that improves gro...
P. Reddy, C. Mandke, Suvrankar Datta et al.· 0 citations
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