Enhancement of Budesonide Dissolution and In-Vivo Pharmacokinetics via Nanoliposomal Drug Delivery System

Formulation and Physicochemical Characterization of Paliperidone- Loaded Niosomal Vesicles for Improved Transdermal Drug Delivery.

INTRODUCTION/OBJECTIVE Niosomes are nonionic surfactant-based vesicular systems. Paliperidone, which is an atypical antipsychotic used in the management of schizophrenia, exhibits poor aqueous solubility and limited oral bioavailability, which could limit its therapeutic effectiveness. This study aimed to develop and o...

Optimized Lamotrigine-Loaded Polymeric Nanoparticles for Enhanced Drug Delivery: A Box-Behnken Design Approach with Integrated In Vivo Evaluation

Lamotrigine-loaded chitosan-sodium alginate polymeric nanoparticle system optimized by BoxBehnken Design demonstrated improved release control, enhanced pharmacokinetic parameters, and superior anticonvulsant activity in vivo, supporting their potential as a sustained-release system for epilepsy management.

Development of Lyophilized Ebastine-Loaded Novasome Tablets: Comprehensive Physicochemical Characterization and In Vitro/In Vivo Release Evaluation.

INTRODUCTION/OBJECTIVE Ebastine, a second-generation H1 antihistamine, exhibits poor aqueous solubility and consequently low oral bioavailability, limiting its clinical therapeutic efficacy. Novasome is an advanced vesicular nanocarrier system that offers a promising approach to enhance the solubility and dissolution b...

Self-emulsifying Delivery System for Improving Biopharmaceutical Performance of a Novel Antitubercular Agent: Formulation Development, Biological Activity and Pharmacokinetic Evaluation

A nitroimidazole-derived lead (IIIM-019) was developed as a part of our institutional drug discovery program in the area of tuberculosis. This molecule suffers from poor aqueous solubility and to overcome this limitation, lipid-based self-emulsifying drug delivery system (SEDDS) was developed. The SEDDS was characteriz...

Development of ursolic acid-loaded cubosomal nanocarriers: enhanced dissolution, pharmacokinetics, bioavailability, and anticancer activity.

Formulation, Characterization and Evaluation of Polymeric Nanospheres-Based Colon-Targeted Delivery of Oxiconazole Nitrate

Oxiconazole nitrate-loaded nanospheres were successfully developed using the emulsification–solvent evaporation method to enhance the solubility and dissolution of oxiconazole nitrate, a Biopharmaceutics Classification System (BCS) Class II antifungal drug characterized by low aqueous solubility and good membrane perme...