SYNTHESIS, CHARACTERIZATION, ANTIOXIDANTANDANTICANCER STUDIES OF COPPER(II) COMPLEXESOF2-AMINOBENZIMIDAZOLE SCAFFOLD SCHIFFBASES
TL;DR
In vitro anticancer activities of the Schiff bases (L1–L4) and their Cu(II) complexes were assessed against HeLa cancer cell lines using the MTT assay, and a hydroxyl-substituted ligand and its Cu(II) complex demonstrated marked cytotoxic activity towards the HeLa cell lines.
Abstract
2-Aminobenzimidazole is a heterocyclic compound of significant interest in drug design and materials science dueto its ability to interact with biological systems and coordinate metal ions, making it useful for both pharmaceutical and industrial applications. Novel Cu(II) complexes (L1Cu–L4Cu) were synthesised using Schiff base ligands (L1–L4) prepared by condensing 2-aminobenzimidazole with various aromatic aldehydes, includingp- chlorobenzaldehyde, p-methoxybenzaldehyde, 3,4,5-trimethoxybenzaldehyde, and p-hydroxybenzaldehyde. TheSchiff base ligands and their copper (II) complexes were characterised using magnetic susceptibility, molar conductance, electronic, FT-IR, Nuclear magnetic resonance, and mass spectrum analyses. Spectral analysessuggested all Copper(II) complexes have a geometry of square planar. Ligands (L1–L4) and Copper(II) complexeswere examined for antioxidant behaviour using DPPH, and the findings showed that compounds containing methoxygroups exhibited higher activity than the others. Moreover, in vitro anticancer activities of the Schiff bases (L1–L4) and their Cu(II) complexes were assessed against HeLa cancer cell lines using the MTT assay. The findings exposeda hydroxyl-substituted ligand and its Cu(II) complex demonstrated marked cytotoxic activity towards the HeLa cell lines.