TPT 1.16 Concurrent Breast and Colon Cancer – Small Cohort Analysis

Abstract

Multiple primary malignant neoplasms (MPMNs) are increasingly recognized due to improved diagnostics and prolonged survival. This retrospective report analyzes the clinicopathological characteristics and management of female patients diagnosed with both bowel and breast cancers. Twelve female patients treated for both breast and colonic cancers between 2015 and 2025 were reviewed. The study analyzed demographics, clinical presentation, pathology, genetic associations, and management approaches. Patient ages ranged from 56 to 84 (mean: 70). Seven cases were synchronous; of these, three presented with a breast lump, while four breast primaries were incidental findings during colon cancer staging. Breast histology was predominantly invasive carcinoma of no special type. Colonic tumors were adenocarcinomas in 91% of the cohort. Unique cases included a coexisting neuroendocrine tumor and an anal squamous cell carcinoma. Curative surgery was performed in 75% of breast cases and 91% of colonic cases. The overall mortality rate was 8.3%. MPMNs are being reported more frequently due to the rising prevalence of elderly cancer survivors and heightened clinical awareness. The concurrence of breast and colonic cancers can occur without known risk factors. These complex cases require an individualized approach within a multidisciplinary care framework.