Mechanochemistry as an Emerging Tool for Organofluorine Chemistry

Abstract

Owing to the unique properties of the fluorine atom, fluorinated scaffolds have become pivotal compounds in the pharmaceutical and agrochemical industries, as well as in materials science. Consequently, the development of versatile and efficient strategies for the synthesis of organofluorine compounds has attracted considerable attention. However, designing such methodologies while simultaneously addressing contemporary sustainability challenges is a critical objective. In this context, synthetic mechanochemistry, which relies on mechanical forces produced by grinding or milling, for instance, to activate organic molecules, has emerged as a viable and sustainable alternative to conventional solution‐phase chemistry. Beyond its environmental benefits, solvent‐free conditions often enhance reactivity and selectivity, shorten reaction times, and minimize synthetic waste. In addition, this approach enables the use of poorly soluble reactants, thereby unlocking new reaction pathways. This review focuses on recent advances in the mechanochemical synthesis of fluorinated compounds and highlights the advantages of mechanical activation as an enabling platform for modern organofluorine chemistry.