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Review Open access Sep 2026

THE POTENTIAL ROLE OF L-CARNITINE SUPPLEMENTATION IN MANAGEMENT OF POLYENDOCRINE METABOLIC OVARIAN SYNDROME

Current data suggest that L-carnitine supplementation may improve metabolic parameters, including insulin resistance and lipid profiles, while exerting antioxidant and anti-inflammatory effects in ovarian tissue, but clinical evidence is limited by heterogeneity in study design, small sample sizes, and reliance on surr...

Melania Czapla, Karolina Kubala, Julia Tesyna et al. · 0 citations
Review Open access Sep 2026

Ketoanalogues of Essential Amino Acids in Chronic Kidney Disease: From Biochemical Rationale to Conditions for Clinical Effectiveness

KA/EAA-supplemented VLPD may delay kidney replacement therapy in appropriately selected and supervised patients, but the supplement should be prescribed as part of a complete nutritional strategy rather than as an autonomous drug.

A. Cupisti, C. D'Alessandro, Vincenzo Panichi et al. · 0 citations
Review Open access Sep 2026

Beyond Standard Renoprotection: Palm Tocotrienol-Rich Vitamin E and Multi-Hit Residual Renal Risk in Diabetic Kidney Disease-A Translational Review

A Multi-Hit Residual Renal Risk (MHR3) model is proposed in which evidence-based pharmacotherapy constitutes the therapeutic foundation and tocotrienols are positioned only as an investigational adjunct targeting incompletely controlled biological injury.

Loso Judijanto · 0 citations
Open access Sep 2026

Iatrogenic hypercalcemia in a patient with type 2 diabetes and chronic kidney disease

A 59-year-old man with obesity, type 2 diabetes, CKD stage 3b, albuminuria and established cardiovascular disease receiving optimized treatment with renin–angiotensin–aldosterone system blockade, sodium-glucose cotransporter-2 inhibition, semaglutide and finerenone develops symptomatic severe non-parathyroid hormone-me...

M. Mačković, N. Marić, I. Kralj et al. · 0 citations
Review Sep 2026

Mechanisms of Aging in Phenylketonuria (PKU).

A narrative review synthesizes the current evidence on accelerated aging in PKU, describes its clinical manifestations, and proposes potential aging biomarkers and treatment targets.

John Bassett, Neve Cufflin, Iain P Hargreaves et al. · 0 citations
Review Open access Oct 2026

Periostin in diabetic kidney disease: mechanistic insights, biomarkers, and therapeutic perspectives

Diabetic kidney disease (DKD) is among the most common and severe microvascular complications of diabetes and represents a leading cause of end-stage renal disease (ESRD) worldwide. Currently, although strict glycemic and blood pressure control, together with the use of renin–angiotensin system inhibitors, sodium-gluco...

Xu-Hao Li, Ya-Miao Wu, Ye-Xuan Shi et al. · 0 citations

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