Prospective validation of a urine-based proteomics test for predicting clinically significant prostate cancer in biopsy-naïve patients.

Precision Diagnostics in Prostate Cancer: Integrating Biomarkers, Imaging, Genomics, and Artificial Intelligence in Contemporary United States Practice

This review critically examines contemporary prostate cancer diagnostics within United States clinical practice, distinguishing established guideline-supported approaches from selectively used adjuncts and emerging technologies.

Recent advances in discriminating prostate cancer from benign prostatic diseases in the pre-biopsy population

Urinary Proteomics Enables Non-Invasive and Longitudinal Monitoring of Tumor Burden Dynamics and Early Recurrence in HCC.

PURPOSE To develop a non-invasive, urine-based approach for dynamic monitoring of tumor burden and early detection of recurrence in hepatocellular carcinoma (HCC), addressing the limited sensitivity of conventional serum biomarkers such as AFP and DCP, particularly for minimal residual disease (MRD) assessment. METHO...

Combined Urinary Prostate Cancer Risk Score Based on Levels of PCAT14, PCA3, SChLAP1, and TMPRSS2: ERG Biomarkers Detected Using Resistive Sensors

Prostate cancer is a common age-related malignancy among men, originating in the prostate epithelium, often asymptomatic in early stages. The first line of diagnosis, serum prostate-specific antigen evaluations, suffers from low specificity and sensitivity, leading to false positives and missed clinically significant c...

Emerging serum and urine biomarkers for non-invasive detection, risk stratification and prognostic assessment of prostate cancer: a systematic review

This review synthesised current evidence on emerging serum and urine protein biomarkers with diagnostic, prognostic, and predictive relevance for non-invasive PCa detection and risk stratification. A systematic search of PubMed, Scopus, and ScienceDirect was conducted for studies published between January 2006 and Dece...

B-077 Multicenter Comparison of PSA Immunoassays: Analytical Bias and Its Impact on Prostate Cancer Screening

Prostate-specific antigen (PSA) testing plays a central role in prostate cancer screening and management, guiding clinical decisions from initial detection to biopsy and follow-up. However, total PSA (tPSA) results can vary across commercial immunoassays due to lack of testing harmonizations, potentially altering...