2026· International review of neurobiology· Vol 187, pp.
1-16
· 0 citations
Medicine
TL;DR
This review synthesizes evidence from genetic, biochemical, and neuropathological studies to highlight shared molecular nodes, such as ESCRT-III components, the VPS4 ATPase, the adaptor protein ALIX, and late endosomal regulators, including Rab7 that couple membrane remodeling to autophagic flux.
The latest research delineating the landscape and network of autophagy in developing and mature neurons is reviewed, elucidating how conserved autophagy pathways regulate neuronal homeostasis and functions at different ages.
Henry Kim, E. Wickstead, Xiaoting Zhou et al.· Nature Neuroscience· 0 citations
Regulation of mitochondrial health is critical for maintaining cellular homeostasis in the nervous system. Damaged mitochondria can have detrimental effects on neuronal health and are thought to be key contributors to the progression of neurodegenerative disorders including Parkinson’s disease and amyotrophic lateral s...
Bishal Basak, Julia F. Riley, Neha M. Nataraj et al.· Journal of Clinical Investig...· 0 citations
It is suggested that enhancing or improving autophagy function may be an effective treatment method to alleviate the condition of AD patients, which can provide new strategies for clinical treatment and intervention of AD in the future.
Kun Lu, Yirui Lu, Runyu Tang et al.· Journal of Alzheimer's Disea...· 0 citations
A synthesis of emerging evidence supporting an integrated 'Autophagy-Senescence-Inflammasome (ASI) axis' is synthesised, in which reciprocal interactions among impaired autophagy, senescent glia, and inflammasome signalling establish a self-sustaining cycle of neuroinflammation.
Surendar Ellappan, Punit Prasanna Kujur, A. C. Mondal· Ageing Research Reviews· 1 citation
In insights on the research regarding therapeutic approaches of NDs which intend to target molecular components, a general understanding of proteostasis, ER stress, UPR signalling and how these cellular processes are related to neurodegeneration is provided.
E. Çoban, A. Cerkezkayabekir· Neurochemical Journal· 0 citations
It is demonstrated that G3BP1 also stabilises the COPI vesicle protein beta-COP by promoting its interaction with the deubiquitinase USP10, which accelerates its proteasomal degradation.
Sarayu Ramakrishna, Laura Ryan, Sung-Min Son et al.· Cell Death and Differentiati...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
