Inflammatory–metabolic burden and its correlates in patients with gout: a case–control study

Abstract

Aims: To evaluate cumulative advanced glycation end product accumulation measured by skin autofluorescence (AGE-SAF) in patients with gout and to investigate its associations with inflammatory burden, renal function, metabolic parameters, and the C-reactive protein–albumin–lymphocyte (CALLY) index. Methods: This cross-sectional case–control study included 45 patients with gout and 45 age- and gender-comparable healthy controls. AGE accumulation was assessed noninvasively using skin autofluorescence (AGE-SAF). Demographic, clinical, inflammatory, metabolic, and renal variables were recorded. Correlation analyses, subgroup comparisons, receiver operating characteristic (ROC) analysis, false discovery rate (FDR)-corrected analyses, and multivariable linear regression models were performed. Results: Patients with gout had significantly higher AGE-SAF levels than healthy controls (2.46±0.69 vs. 1.83±0.24 AU, p